Paneth Cell Hyperplasia and Metaplasia in Hirschsprung-associated Enterocolitis in An Aganglionosis Rat Model

Iskandar Rahardjo Budianto; Agus Firmansyah; Yefta Moenadjat; Ahmad Aulia Jusuf; Vivian Soetikno

doi:10.18585/INABJ.V14I4.2007

Paneth Cell Hyperplasia and Metaplasia in Hirschsprung-associated Enterocolitis in An Aganglionosis Rat Model

Iskandar Rahardjo Budianto, Agus Firmansyah, Yefta Moenadjat, Ahmad Aulia Jusuf, Vivian Soetikno

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

BACKGROUND: Many hypotheses regarding the pathophysiology of enterocolitis in aganglionic megacolon or Hirschsprung disease (HSCR) has been proposed. Paneth cells are columnar intestinal epithelial cells that have an important role in maintaining of intestinal homeostasis as a bactericide. Since enterocolitis in HSCR may have association with Paneth cells metaplasia and hyperplasia, current study investigated Paneth cells metaplasia and hyperplasia in the sigmoid colon of HSCR rat model and its products, namely a-defensins and IL-1b, in the sigmoid colon tissues.

Original language	English
Pages (from-to)	393-400
Number of pages	8
Journal	Indonesian Biomedical Journal
Volume	14
Issue number	4
DOIs	https://doi.org/10.18585/INABJ.V14I4.2007
Publication status	Published - 2022

Keywords

Animal model
Defensins
Enterocolitis
Hirschsprung
Metaplasia
Paneth cell

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10.18585/INABJ.V14I4.2007

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title = "Paneth Cell Hyperplasia and Metaplasia in Hirschsprung-associated Enterocolitis in An Aganglionosis Rat Model",

abstract = "BACKGROUND: Many hypotheses regarding the pathophysiology of enterocolitis in aganglionic megacolon or Hirschsprung disease (HSCR) has been proposed. Paneth cells are columnar intestinal epithelial cells that have an important role in maintaining of intestinal homeostasis as a bactericide. Since enterocolitis in HSCR may have association with Paneth cells metaplasia and hyperplasia, current study investigated Paneth cells metaplasia and hyperplasia in the sigmoid colon of HSCR rat model and its products, namely a-defensins and IL-1b, in the sigmoid colon tissues.",

keywords = "Animal model, Defensins, Enterocolitis, Hirschsprung, Metaplasia, Paneth cell",

author = "Budianto, {Iskandar Rahardjo} and Agus Firmansyah and Yefta Moenadjat and Jusuf, {Ahmad Aulia} and Vivian Soetikno",

note = "Funding Information: We thank Yulvian Sani, PhD for the technical assistance. This study was supported by the Director of Research and Development, Universitas Indonesia with the grant number NKB-491/UN2.RST/HKP.05.00/2021. Publisher Copyright: {\textcopyright} 2022, Indonesian Biomedical Journal. All Rights Reserved.",

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doi = "10.18585/INABJ.V14I4.2007",

language = "English",

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AU - Budianto, Iskandar Rahardjo

AU - Firmansyah, Agus

AU - Moenadjat, Yefta

AU - Jusuf, Ahmad Aulia

AU - Soetikno, Vivian

N1 - Funding Information: We thank Yulvian Sani, PhD for the technical assistance. This study was supported by the Director of Research and Development, Universitas Indonesia with the grant number NKB-491/UN2.RST/HKP.05.00/2021. Publisher Copyright: © 2022, Indonesian Biomedical Journal. All Rights Reserved.

PY - 2022

Y1 - 2022

N2 - BACKGROUND: Many hypotheses regarding the pathophysiology of enterocolitis in aganglionic megacolon or Hirschsprung disease (HSCR) has been proposed. Paneth cells are columnar intestinal epithelial cells that have an important role in maintaining of intestinal homeostasis as a bactericide. Since enterocolitis in HSCR may have association with Paneth cells metaplasia and hyperplasia, current study investigated Paneth cells metaplasia and hyperplasia in the sigmoid colon of HSCR rat model and its products, namely a-defensins and IL-1b, in the sigmoid colon tissues.

AB - BACKGROUND: Many hypotheses regarding the pathophysiology of enterocolitis in aganglionic megacolon or Hirschsprung disease (HSCR) has been proposed. Paneth cells are columnar intestinal epithelial cells that have an important role in maintaining of intestinal homeostasis as a bactericide. Since enterocolitis in HSCR may have association with Paneth cells metaplasia and hyperplasia, current study investigated Paneth cells metaplasia and hyperplasia in the sigmoid colon of HSCR rat model and its products, namely a-defensins and IL-1b, in the sigmoid colon tissues.

KW - Animal model

KW - Defensins

KW - Enterocolitis

KW - Hirschsprung

KW - Metaplasia

KW - Paneth cell

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DO - 10.18585/INABJ.V14I4.2007

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JO - Indonesian Biomedical Journal

JF - Indonesian Biomedical Journal

IS - 4

ER -

Paneth Cell Hyperplasia and Metaplasia in Hirschsprung-associated Enterocolitis in An Aganglionosis Rat Model

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Keywords

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