[P4–339]: RATIO OF ODDS RATIO ANALYSIS OF RISK FACTORS BETWEEN INDONESIAN EARLY ONSET AND LATE ONSET ALZHEIMER's DISEASE: RSCM's 2008–2015 DEMENTIA REGISTRY STUDY

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Abstract

Background
Previous researches described different pathomechanism of Early Onset Alzheimer's Disease (EOAD) and Late Onset Alzheimer's Disease (LOAD), and various risk factors differences between the two groups on many countries. Indonesia is a developing country with huge population, largest moslem population in the world, consisting of so many ethnic and tribes, yet had not published its determinant risk factor study for EOAD and LOAD. This study attempted to determine risk factors Odds Ratio (OR) difference on EOAD and LOAD in Indonesia, represented by one of its tertiary referral hospital, the Cipto Mangunkusumo Hospital (RSCM).

Methods
This descriptive analytic, cross-sectional study analyzed various risk factors' OR of EOAD (onset age <65 year old) and LOAD (onset age ≥ 65 year old) in RSCM. Data were collected from The Memory Clinic 2008–2015 Dementia Registry of RSCM. There were 185 AD patients and 403 normal subjects. Multivariate analysis logistic regression and Altman-Bland method were used to determine the Ratio of Odds Ratio (ROR) between LOAD and EOAD at RSCM. All analysis assumed LOAD as first group and EOAD as the second group. ROR <1 means LOAD group had less risk than EOAD and ROR>1 means LOAD had more risk than EOAD. Statistical significance is defined as confidence interval of ROR not crossing 1.

Results
Family history of dementia (ROR 0.79, CI 0.35–1.82, p=0.34), hypertension (ROR 1.01, CI 0.47–2.16, p=0.40), diabetes mellitus (ROR 0.45, CI 0.22–0.92, p=0.04), dyslipidemia (ROR 0.43, CI 0.18–1.02, p=0.06), smoking (ROR 1.57, CI 0.51–4.85, p=0.30), cerebrovascular history (ROR 0.35, CI 0.17–0.73, p=0.01) and history of traumatic brain injury (ROR 2.06, CI 0.66–6.44, p=0.18).

Conclusions
DM and cerebrovascular history had significantly greater OR on EOAD compared to LOAD, suggesting that vascular factors play important role in pathogenesis of EOAD.
Original languageEnglish
Title of host publicationAlzheimer's Association International Conference
Volume13
Edition7S_Part_29
DOIs
Publication statusPublished - 1 Jul 2017

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