TY - JOUR
T1 - Outcome analysis and prognostic factors in patients of glioblastoma multiforme
T2 - An indonesian single institution experience
AU - Sudibio, Sudibio
AU - Anton, Jellyca
AU - Handoko, Handoko
AU - Permata, Tiara Bunga Mayang
AU - Kodrat, Henry
AU - Nuryadi, Endang
AU - Sofyan, Henry Riyanto
AU - Mulyadi, Rahmad
AU - Aman, Renindra Ananda
AU - Gondhowiardjo, Soehartati
N1 - Funding Information:
Universitas Indonesia-PUTI Grant with contract number NKB 4715/UN2.RST/HKP.05.00/2020.
Publisher Copyright:
© 2021 Sudibio Sudibio, Jellyca Anton, Handoko Handoko, Tiara Bunga Mayang Permata, Henry Kodrat, Endang Nuryadi, Henry Riyanto Sofyan, Rahmad Mulyadi, Renindra Ananda Aman, Soehartati Gondhowiardjo.
PY - 2021/12/26
Y1 - 2021/12/26
N2 - AIM: This study was done to assess the survival of patients with glioblastoma multiforme (GBM) and to identify factors that can affect patient survival. MATERIALS AND METHODS: From January 2015 to December 2019, 55 patients with histopathologically confirmed GBM and received adjuvant radiation/chemoradiation in our department were retrospectively analyzed. RESULTS: The median overall survival (OS) for entire cohort was 13 months and 1-year OS and 2-year OS rate were 52.7% and 3.6% with the mean follow-up period was 12 months. In univariate analysis, age (≤50 years vs. >50 years, p = 0.02), performance status (≥90 vs. 70–80 vs. <70, p < 0.001), radiation therapy oncology group recursive partitioning analysis (RTOG-RPA) classification (Class III vs. Class IV vs. Class V-VI, p < 0.001), parietal lobes tumor site (vs. others, p = 0.02), residual tumor volume (≤20.4 cm3 vs. >20.4 cm3, p = 0.001), and time to initiate adjuvant therapy (<4 weeks vs. 4-6 weeks vs. >6 weeks, p = 0.01) were significantly affect OS. In multivariate analysis, RTOG-RPA classification and involvement of parietal lobes were independent prognostic factors for OS. CONCLUSIONS: RTOG-RPA classification that consisted of age and performance status is an independent prognostic factor for the clinical outcome of GBM. Besides this well-known factor, we also identified the involvement of parietal lobe gives a strong negative influence on survival of GBM patients.
AB - AIM: This study was done to assess the survival of patients with glioblastoma multiforme (GBM) and to identify factors that can affect patient survival. MATERIALS AND METHODS: From January 2015 to December 2019, 55 patients with histopathologically confirmed GBM and received adjuvant radiation/chemoradiation in our department were retrospectively analyzed. RESULTS: The median overall survival (OS) for entire cohort was 13 months and 1-year OS and 2-year OS rate were 52.7% and 3.6% with the mean follow-up period was 12 months. In univariate analysis, age (≤50 years vs. >50 years, p = 0.02), performance status (≥90 vs. 70–80 vs. <70, p < 0.001), radiation therapy oncology group recursive partitioning analysis (RTOG-RPA) classification (Class III vs. Class IV vs. Class V-VI, p < 0.001), parietal lobes tumor site (vs. others, p = 0.02), residual tumor volume (≤20.4 cm3 vs. >20.4 cm3, p = 0.001), and time to initiate adjuvant therapy (<4 weeks vs. 4-6 weeks vs. >6 weeks, p = 0.01) were significantly affect OS. In multivariate analysis, RTOG-RPA classification and involvement of parietal lobes were independent prognostic factors for OS. CONCLUSIONS: RTOG-RPA classification that consisted of age and performance status is an independent prognostic factor for the clinical outcome of GBM. Besides this well-known factor, we also identified the involvement of parietal lobe gives a strong negative influence on survival of GBM patients.
KW - Glioblastoma multiforme
KW - Prognostic factors
KW - Radiotherapy
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=85119154241&partnerID=8YFLogxK
U2 - 10.3889/oamjms.2021.7502
DO - 10.3889/oamjms.2021.7502
M3 - Article
AN - SCOPUS:85119154241
SN - 1857-5749
VL - 9
SP - 1410
EP - 1416
JO - Open Access Macedonian Journal of Medical Sciences
JF - Open Access Macedonian Journal of Medical Sciences
ER -