Osteocalcin gene polymorphism in indonesian men with periodontitis

Namira Kaulika, Talitha Alwasris, Niniarti Djamal, Benso Sulijaya, Christopher Talbot, Elza Ibrahim Auerkari

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Through this work, we aimed to clarify the association between the severity of periodontitis and osteocalcin (OC) gene C298T polymorphism in Indonesian male subjects. Methods: DNA was extracted from blood serum samples of 100 consenting Indonesian men whose periodontitis was classified as mild, moderate, or severe. Polymerase chain reaction and restriction fragment length polymorphism techniques were applied to evaluate the status of OC (C298T) polymorphism using Hindlll restriction enzyme and electrophoresis in agarose gel to separate the indicated fragments. Results: Although genotype distribution of the OC C298T polymorphism showed a trend for more frequent occurrence of genotype hh (and allele h) with increasing severity of periodontitis, this trend was not statistically significant in the tested sample population, in whom the HH genotype appeared to be relatively rare. Conclusion: The results showed no significant association between the severity of periodontitis and OC C298T polymorphism in Indonesian male subjects.

Original languageEnglish
Pages (from-to)18-20
Number of pages3
JournalInternational Journal of Applied Pharmaceutics
Volume12
Issue numberSpecial Issue 1
DOIs
Publication statusPublished - Mar 2020

Keywords

  • Gene polymorphism
  • Osteocalcin
  • Periodontitis

Fingerprint Dive into the research topics of 'Osteocalcin gene polymorphism in indonesian men with periodontitis'. Together they form a unique fingerprint.

Cite this