Optimizing the Formula of Polymeric-Based Aripiprazole Nanosuspension Using Response Surface Methodology for Intranasal Drug Delivery

Nabila Fatin Aisiah, Silvia Surini

Research output: Contribution to journalArticlepeer-review

Abstract

This study aimed to optimize the formula of aripiprazole nanosuspension for intranasal drug delivery. Response Surface Methodology (RSM) was employed to determine the influence of independent variables, including drug concentration, polymer concentration, and the ratio of polymer combination, on the nanosuspension characteristics. The parameters under investigation were particle size (d mean), polydispersity index, and drug content. Fifteen formulas generated from Box-Behnken Design (BBD) were prepared using the combination of high-shear homogenization–ultrasonication method, and the Design Expert software was applied for optimum formula determination. The result showed significant effects of the independent variables on the nanosuspension characteristics, with particle sizes ranging from 143.6 – 334.6 nm, PDI values of 0.302 – 0.649, and drug content of 98.7 – 102.1%. The predicted optimum formula had a drug concentration of 28 mg/mL in the organic solvent, polymer concentration of 1.5% (w/v), and HPMC to PVP ratio of 1.4 with desirability of 0.94. Additionally, it exhibited desirable characteristics, such as a particle size of 171.2 ± 11.4 nm, a PDI value of 0.317 ± 0.02, and a high drug content of 100.04 ± 0.65%. The optimized formula was also evaluated for its morphology using TEM, in vitro duration of mucoadhesion and physical-chemical stability study. In conclusion, the aripiprazole nanosuspension prepared and optimized using RSM exhibited favorable characteristics, including small particle size, narrow distribution, and high drug content.

Original languageEnglish
Pages (from-to)501-511
Number of pages11
JournalIndonesian Journal of Pharmacy
Volume35
Issue number3
DOIs
Publication statusPublished - 2024

Keywords

  • Aripiprazole
  • High Shear Homogenization
  • Nanosuspension
  • Ultrasonication

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