TY - JOUR
T1 - Optimization of biodegradable PLA/PCL microspheres preparation as controlled drug delivery carrier
AU - Lukmanul Hakim, S.
AU - Kusumasari, Findi Citra
AU - Budianto, Emil
N1 - Publisher Copyright:
© 2019 Elsevier Ltd. All rights reserved.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - In this paper, microspheres were prepared as controlled drug delivery carrier. Microspheres were prepared using o/w emulsification method. The core materials of microspheres were polyblend of poly(lactic acid) (PLA) and poly(ϵ-caprolactone) (PCL) with the composition of 60:40 using Span 80 as an emulsifier. PLA and PCL were dissolved into dichloromethane then emulsified and dispersed into water to form microspheres. The sizes and uniformity of microspheres can be influenced by emulsifier volume and dispersion stirring time. This study observes the appearance, texture, physical sizes, and distribution of microspheres particle sizes at various volumes of Span 80 and dispersion stirring time. The blend of PLA and PCL was only formed through physical interaction between them. The appearance and physical sizes of microspheres were observed by optical microscope, and the distribution sizes of the microsphere can be determined by PSA, the further analysis through SEM to observe the surface texture and also to know more the influence of dispersion stirring time to the size and uniformity of microsphere. It obtains that at volume 4 mL of Span 80 with dispersion stirring time of 30 minutes showing the small sizes and more uniform as well as just fewer microspheres were broken.
AB - In this paper, microspheres were prepared as controlled drug delivery carrier. Microspheres were prepared using o/w emulsification method. The core materials of microspheres were polyblend of poly(lactic acid) (PLA) and poly(ϵ-caprolactone) (PCL) with the composition of 60:40 using Span 80 as an emulsifier. PLA and PCL were dissolved into dichloromethane then emulsified and dispersed into water to form microspheres. The sizes and uniformity of microspheres can be influenced by emulsifier volume and dispersion stirring time. This study observes the appearance, texture, physical sizes, and distribution of microspheres particle sizes at various volumes of Span 80 and dispersion stirring time. The blend of PLA and PCL was only formed through physical interaction between them. The appearance and physical sizes of microspheres were observed by optical microscope, and the distribution sizes of the microsphere can be determined by PSA, the further analysis through SEM to observe the surface texture and also to know more the influence of dispersion stirring time to the size and uniformity of microsphere. It obtains that at volume 4 mL of Span 80 with dispersion stirring time of 30 minutes showing the small sizes and more uniform as well as just fewer microspheres were broken.
KW - Microspheres
KW - Poly(lactic acid)
KW - Poly(ϵ-caprolactone)
KW - Span 80
UR - http://www.scopus.com/inward/record.url?scp=85081980375&partnerID=8YFLogxK
U2 - 10.1016/j.matpr.2019.08.156
DO - 10.1016/j.matpr.2019.08.156
M3 - Conference article
AN - SCOPUS:85081980375
SN - 2214-7853
VL - 22
SP - 306
EP - 313
JO - Materials Today: Proceedings
JF - Materials Today: Proceedings
T2 - 2018 2nd International Conference on Nanomaterials and Biomaterials, ICNB 2018
Y2 - 10 December 2018 through 12 December 2018
ER -