Optic neuropathy in breast malignancy

S. Nusanti, Y. A. Laksmita, M. Sidik

Research output: Contribution to journalArticlepeer-review


Purpose: To report a case in which a woman developed an optic disc abnormality that was related to breast malignancy. Case Presentation: A 35-year-old woman presented with a complaint of sudden blurred vision in her right eye(RE). She had a history of Sjögren syndrome and recurrent dyspnea. Visual acuity in her RE was only slightly reduced, but the visual field defect was prominent. Funduscopy was significant for a blunted optic nerve head margin with surrounding whitish lesion. Autoimmune optic neuropathy was initially suspected due to her history of Sjögren syndrome; therefore, an oral steroid was administered. During subsequent follow-up, the fundus abnormality became more visible and expanded to the retinal background, accompanied by a worsening visual field. Systemic evaluation revealed a breast malignancy, and the patient was diagnosed with malignancy-related optic neuropathy. Conclusion: Optic nerve abnormality due to malignancy remains among the most challenging diseases in diagnosis. In this case, the patient presented with a history of autoimmune disease and no known oncologic history. Evaluation of such patients should include a comprehensive systemic survey in order to find clues for the etiology, including the possibility of malignancy and metastatic disease.

Original languageEnglish
Pages (from-to)106-111
Number of pages6
JournalNeuro-Ophthalmology Japan
Issue number1
Publication statusPublished - 1 Jan 2019


  • Autoimmune disease
  • Breast malignancy
  • Metastatic disease
  • Optic neuropathy
  • Sjogren syndrome


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