One-pot synthesis of spirooxindole-pyrrolizidine compounds using magnetically separable Fe3O4-graphene oxide (Fe3O4-GO) catalyst

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A couple of novel Spirooxindole-pyrrolizidine compounds have been synthesized from chalcone derivatives as α, β-unsaturated carbonyl compounds by the help of heterogeneous magnetically separable Fe3O4-GO catalyst. Four steps involved in this research are synthesis of Fe3O4-GO catalyst, synthesis of chalcone derivatives from 4-hydroxybenzaldehyde and cinnamaldehyde, synthesis of spirooxindole-pyrrolizidine derivatives by 1,3-dipolar-cycloaddition reaction through the formation of azomethine ylide, and the last is antioxidant activity assay using DPPH method. The result showed that the use of Fe3O4-GO catalyst as much as 5 wt% can increase the reaction yield to 86.27 %. From the DPPH assay, it is known that spirooxindole-pyrrolizidine derivatives have an antioxidant activity but spirooxindole-pyrrolizidine derived from 4-hydroxybenzaldehyde is the better one.

Original languageEnglish
Article number012014
JournalIOP Conference Series: Materials Science and Engineering
Issue number1
Publication statusPublished - 2020
Event4th International Symposium on Current Progress in Functional Materials, ISCPFM 2019 - Bali, Indonesia
Duration: 6 Nov 20197 Nov 2019


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