One-Pot Synthesis of 2-Phenylquinoline-4-Carboxylic Acid: Iron(III) Trifluoromethanesulfonate Catalysed Doebner Reaction

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Iron(III) trifluoromethanesulfonate [Fe(OTF)3] has been proven to be an effective catalyst in the synthesis of 2-phenylquinoline-4-carboxylic acid by the Doebner reaction using one-pot pyruvic acid, aniline, and benzaldehyde. This method shows attractive characteristics including concise one-pot conditions, high atom economy, very limited energy consumption, and the sequential catalytic process requires only a catalytic (15 mol%) amount of Fe(OTf)3 with short reaction periods (3 h) . Meanwhile, the catalyst was easily recovered from the reaction system and reused smoothly with only a little loss of activity.

Original languageEnglish
Title of host publicationAdvanced Materials Science and Technologies II - Selected peer-reviewed full text papers from 5th International Conference on Materials Sciences and Nanomaterials, ICMSN 2021 and 4th International Conference on Advanced Composite Materials, ICACM 2021
EditorsYuyuan Zhao
PublisherTrans Tech Publications Ltd
Pages97-102
Number of pages6
ISBN (Print)9783035718942
DOIs
Publication statusPublished - 2022
Event5th International Conference on Materials Sciences and Nanomaterials, ICMSN 2021 and 4th International Conference on Advanced Composite Materials, ICACM 2021 - Virtual, Online
Duration: 25 Aug 202127 Aug 2021

Publication series

NameKey Engineering Materials
Volume907 KEM
ISSN (Print)1013-9826
ISSN (Electronic)1662-9795

Conference

Conference5th International Conference on Materials Sciences and Nanomaterials, ICMSN 2021 and 4th International Conference on Advanced Composite Materials, ICACM 2021
CityVirtual, Online
Period25/08/2127/08/21

Keywords

  • 2-phenylquinoline-4-carboxylic acid
  • Doebner reaction
  • Iron(III) trifluoromethanesulfonate
  • one-pot reaction

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