One-pot four-component synthesis of phenazine derivative using 2-hydroxy-1,4-naphthoquinone

A. H. Cahyana, N. Nazhifah, A. R. Liandi

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Phenazine is one of the most important organic compounds because of its various biological activities. This study aims to synthesize the phenazine derivatives compound using 2-hydroxy-1,4-naphthoquinone (lawsone) with a one-pot four-component method.Phenazine derivative that had been successfully synthesized was carried out by reacting four reactants at once in one flask with the same mole ratio. The reaction occurred between lawsone, o-phenylenediamine, benzaldehyde, and malononitrile. Characterization of the synthesized products was confirmed using FT-IR, UV-Vis Spectrophotometer, and LC-MS. The results of the analysis using several of these instruments obtained one compound, namely 3-amino-2-cyano-1-phenyl-1H-benzo[a]pyrano[2,3-c]phenazine. The reaction conditions were carried out at 50 C for 6 h in ethanol with unassisted catalysts and obtained a product yield of 45%.

Original languageEnglish
Article number012020
JournalIOP Conference Series: Materials Science and Engineering
Issue number1
Publication statusPublished - 2020
Event4th International Symposium on Current Progress in Functional Materials, ISCPFM 2019 - Bali, Indonesia
Duration: 6 Nov 20197 Nov 2019


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