TY - JOUR
T1 - Objective Diagnosis of Migraine without Aura with Migraine Vascular Index
T2 - A Novel Formula to Assess Vasomotor Reactivity
AU - Harris, Salim
AU - Rasyid, Al
N1 - Publisher Copyright:
© 2020 The Authors
PY - 2020/6
Y1 - 2020/6
N2 - This pilot study was aimed at developing an objective method to diagnose migraine by measuring the difference in vasomotor reactivity between migraineurs and non-migraineurs. Thirty patients diagnosed with migraine without aura and 30 healthy patients were recruited. Vasomotor reactivity of all patients was then assessed by measuring the breath holding index (BHI), hyperventilation index and a novel formula, the migraine vascular index (MVI), of the middle cerebral artery using transcranial Doppler ultrasonography. Migraineurs were found to have significantly lower BHI and MVI values (p < 0.001). Logistic regression analysis revealed that MVI was a significant independent predictor of migraine (p = 0.007). The sensitivity and specificity of MVI in diagnosing migraine with a cutoff value of 1.035 were 86.7% and 86.7%, respectively. In conclusion, MVI measurement is a reliable method for objectively diagnosing migraine. Further research is needed to validate the usage of MVI for migraine diagnosis.
AB - This pilot study was aimed at developing an objective method to diagnose migraine by measuring the difference in vasomotor reactivity between migraineurs and non-migraineurs. Thirty patients diagnosed with migraine without aura and 30 healthy patients were recruited. Vasomotor reactivity of all patients was then assessed by measuring the breath holding index (BHI), hyperventilation index and a novel formula, the migraine vascular index (MVI), of the middle cerebral artery using transcranial Doppler ultrasonography. Migraineurs were found to have significantly lower BHI and MVI values (p < 0.001). Logistic regression analysis revealed that MVI was a significant independent predictor of migraine (p = 0.007). The sensitivity and specificity of MVI in diagnosing migraine with a cutoff value of 1.035 were 86.7% and 86.7%, respectively. In conclusion, MVI measurement is a reliable method for objectively diagnosing migraine. Further research is needed to validate the usage of MVI for migraine diagnosis.
KW - Breath holding index
KW - Diagnosis
KW - Hyperventilation index
KW - Migraine
KW - Migraine vascular index
KW - Transcranial Doppler ultrasonography
UR - http://www.scopus.com/inward/record.url?scp=85081297657&partnerID=8YFLogxK
U2 - 10.1016/j.ultrasmedbio.2020.01.012
DO - 10.1016/j.ultrasmedbio.2020.01.012
M3 - Article
AN - SCOPUS:85081297657
SN - 0301-5629
VL - 46
SP - 1359
EP - 1364
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
IS - 6
ER -