@article{f9ef67ba09b945c4a84b444d62ded3eb,
title = "Novel Interactions of Myristic Acid and FADS3 Variants Predict Atopic Dermatitis among Indonesian Infants",
abstract = "Fatty acids exert a range of different biological activities that could be relevant in the development of atopic dermatitis (AD). This study investigated the association of glycerophospholipid fatty acids (GPL-FA) with AD, and their interactions with single nucleotide polymorphisms (SNP) of the FADS1-3 gene cluster. Among 390 infants of the Indonesian ISADI study, GPL-FA were measured in umbilical plasma (P-0y) and in buccal cells at birth (B-0y), and again in buccal cells at AD onset or one year (B-1y). Prospective and cross-sectional associations with AD were assessed by logistic regression. Interactions of GPL-FA with 14 SNP were tested assuming an additive model. AD was diagnosed in 15.4% of participants. In B-1y, C18:2n-6 was inversely associated with AD; and positive associations were observed for C18:1n-9, C20:4n-6, C22:6n-3 and C20:4n-6/C18:2n-6. There were no prospective associations with AD, however, a significant interaction between the SNP rs174449 and B-0y C14:0 (myristic acid) was observed. This study indicates that Indonesian infants with AD have increased rates of endogenous long-chain polyunsaturated fatty acid production, as well as higher C18:1n-9 levels. GPL-FA measured at birth do not predict later AD incidence; however, genotype interactions reveal novel effects of myristic acid, which are modified by a FADS3 variant.",
keywords = "atopic dermatitis, FADS gene variants, fatty acids, infants, metabolism",
author = "Conny Tanjung and Harris, {Carla P.} and Hans Demmelmair and Sarah Dwitya and Zakiudin Munasir and Herawati Sudoyo and Marie Standl and Sjarif, {Damayanti Rusli} and Berthold Koletzko",
note = "Funding Information: This research was funded by the Commission of the European Communities with the European Research Council Advanced Grant META-GROWTH (ERC-2012- AdG 322605) and the Mead Johnson Pediatric Nutrition Institute (grant 8670 to CT). The funders had no influence on the design, implementation, analysis, and interpretation of the data. Funding Information: C.T., C.P.H., H.D., S.D., Z.M., H.S., M.S. and D.R.S. declare no conflict of interest. B.K. is the Else Kr{\"o}ner Senior professor of Paediatrics at LMU–University of Munich, financially supported by Else Kr{\"o}ner-Fresenius-Foundation, LMU Medical Faculty and LMU University Hospitals. As member of the German National Breastfeeding Committee, chair of the Nutrition Committee, German Paediatric Society and President, the Int Soc Research in Human Milk & Lactation, B.K. tends to be biased towards breastfeeding. LMU and its employee B.K. received support for scientific and educational activities from the European Commission, H2020 Programmes DYNAHEALTH-633595 und Lifecycle-733206, European Research Council Advanced Grant META-GROWTH ERC-2012-AdG–no.322605, EU Erasmus+ Early Nutrition eAcademy Southeast Asia-573651-EPP-1-2016-1-DE-EPPKA2-CBHE-JP and Capacity Building to Improve Early Nutrition and Health in South Africa-598488-EPP-1-2018-1-DE-EPPKA2-CBHE-JP, EU Interreg Programme Focus in CD-CE111, EU Danube Programme CD-Skills DTP3-572-1.2, EU Joint Programming Initiative JPI HDL Nutri PROGRAM and End Obesity, the German Ministry of Education and Research, Berlin (01 GI 0825 and 01EA1904), German Federal Ministry of Health 1503-68403-2021, German Research Council Ko912/12-1 and INST 409/224-1 FUGG, Alexander von Humboldt Foundation 3.3-1218469-POL-HFST-E, US National Institutes of Health 1R03HD087606-01A1, Else Kr{\"o}ner Fresenius Foundation, Family Larsson Rosenquist Foundation, and different healthcare and nutrition companies, predominantly as part of public funded research projects supported by the European Commission or German government. No conflict of interest is declared with no circumstances involving the risk that the professional judgment or acts of primary interest may be unduly influenced by a secondary interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. Publisher Copyright: {\textcopyright} 2022 by the authors.",
year = "2022",
month = nov,
doi = "10.3390/nu14214676",
language = "English",
volume = "14",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "21",
}