Nitrite Test for Optimizing Diagnosis of Asymptomatic Urinary Tract Infection in Pregnant Women: An Evidence-based report

Felix Firyanto Widjaja, Adly Nanda Al Fattah, Dyah Widyowati, Retnani Budiningsih, Nirk Faiz, Rr. Dyah Purnamasari Sulistianingsih

Research output: Contribution to journalArticlepeer-review

Abstract

Asymptomatic urinary tract infections (UTIs) in pregnant women who are not treated appear more likely to develop serious complications on occassional life threatening and risk to deliver more low birth weight neonates. Thus, it is necessary to test whether the infection is really present or not. Urine culture as the gold standard examination still has limitations. This report was made to examine nitrite as a component of urinalysis to be an alternative test for asymptomatic UTIs. A search was conducted on PubMed,® Proquest,® Cochcrane® and Embase.® After screening titles and abstracts by inclusion and exclusion criteria, 16 original articles were found, but only 4 articles were used by author. All four articles showed high negative predictive value (0.82-0.96) and three of them showed good post-test probability (<0.09) when the test result was negative for asymptomatic UTIs. On the other hand, the positive predictive value (0.5-0.69) was poor. Based on the results, nitrite is not strong enough as a sole test for diagnosing asymptomatic UTIs. But, we found that nitrite is good enough to confidently rule out the asymptomatic UTIs in pregnant woman.
Original languageEnglish
JournalJournal of the Indonesian Medical Association : Majalah Kedokteran Indonesia
Publication statusPublished - 2011

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