TY - JOUR
T1 - Nimotuzumab iodine-131 conjugated with MnFe2O4 for potential dual-modality (MRI/SPECT) imaging nanoprobe
AU - Rezka Putra, Amal
AU - Yulizar, Yoki
AU - Ritawidya, Rien
AU - Oky Bagus Apriandanu, Dewangga
AU - Juliyanto, Sumandi
AU - Fikri, Ahsanal
AU - Marcony Surya, Rizki
N1 - Funding Information:
The authors thank the Indonesian Institute of Sciences (LIPI) for providing research opportunities in the degree by research (DBR) program with the Decree of the Head of LIPI No. 184/H/2020. The authors also thank the Center for Radioisotope and Radiopharmaceutical Technology (PTRR) and the Center for Advanced Materials Science and Technology (PSTBM) - National Nuclear Energy Agency (BATAN) for providing the facilities and characterizations.
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/12
Y1 - 2022/12
N2 - Manganese ferrite nanoparticle (MnFe2O4 NPs) has introduced a versatile platform to develop a multifunctional nanosystem for Magnetic Resonance Imaging (MRI) and Single-Photon Emission Computed Tomography (SPECT) modalities. Herein, we develop novel iodine-131-labeled-nimotuzumab conjugated with MnFe2O4 NPs as multimodalities of MRI and SPECT nanoprobe. The synthesis of MnFe2O4 NPs was mediated by Piper nigrum seed extract (PNE) consisting of alkaloids and terpenoids which play essential roles as a weak base source and stabilizing agent in the formation of MnFe2O4 NPs. anti-epidermal Growth Factor Receptor (EGFR) nimotuzumab was conjugated with MnFe2O4 NPs via a heterobifunctional PEG-linker. The radiolabeling of nimotuzumab/MnFe2O4 with iodine-131 was performed using the iodogen method. The vibrational, optical, magnetic, and morphological properties of MnFe2O4 NPs were characterized. MnFe2O4 NPs exhibited a spherical shape with an average particle size of 21 nm with a magnetization value of 23.4 emu/g. The vibrational and structural analyses verify that the MnFe2O4-nimotuzumab was conjugated using a linker. As a result, 131I-labeled-MnFe2O4-nimotuzumab NPs represents an excellent radiochemical purity of 99.32 ± 0.22 %, suggesting that radiopharmaceutical product generates a high imaging quality and unnecessary radiation. In this study, we offer a novel approach to design 131I-labeled-MnFe2O4-nimotuzumab NPs for potential dual-modality MRI and SPECT imaging nanoprobe.
AB - Manganese ferrite nanoparticle (MnFe2O4 NPs) has introduced a versatile platform to develop a multifunctional nanosystem for Magnetic Resonance Imaging (MRI) and Single-Photon Emission Computed Tomography (SPECT) modalities. Herein, we develop novel iodine-131-labeled-nimotuzumab conjugated with MnFe2O4 NPs as multimodalities of MRI and SPECT nanoprobe. The synthesis of MnFe2O4 NPs was mediated by Piper nigrum seed extract (PNE) consisting of alkaloids and terpenoids which play essential roles as a weak base source and stabilizing agent in the formation of MnFe2O4 NPs. anti-epidermal Growth Factor Receptor (EGFR) nimotuzumab was conjugated with MnFe2O4 NPs via a heterobifunctional PEG-linker. The radiolabeling of nimotuzumab/MnFe2O4 with iodine-131 was performed using the iodogen method. The vibrational, optical, magnetic, and morphological properties of MnFe2O4 NPs were characterized. MnFe2O4 NPs exhibited a spherical shape with an average particle size of 21 nm with a magnetization value of 23.4 emu/g. The vibrational and structural analyses verify that the MnFe2O4-nimotuzumab was conjugated using a linker. As a result, 131I-labeled-MnFe2O4-nimotuzumab NPs represents an excellent radiochemical purity of 99.32 ± 0.22 %, suggesting that radiopharmaceutical product generates a high imaging quality and unnecessary radiation. In this study, we offer a novel approach to design 131I-labeled-MnFe2O4-nimotuzumab NPs for potential dual-modality MRI and SPECT imaging nanoprobe.
KW - Iodine-131
KW - Manganese ferrite nanoparticles
KW - MRI/SPECT imaging
KW - Nimotuzumab
KW - Piper nigrum
UR - http://www.scopus.com/inward/record.url?scp=85140050116&partnerID=8YFLogxK
U2 - 10.1016/j.mseb.2022.116016
DO - 10.1016/j.mseb.2022.116016
M3 - Article
AN - SCOPUS:85140050116
SN - 0921-5107
VL - 286
JO - Materials Science and Engineering B: Solid-State Materials for Advanced Technology
JF - Materials Science and Engineering B: Solid-State Materials for Advanced Technology
M1 - 116016
ER -