NILAI DIAGNOSTIK MAGNETIC RESONANCE IMAGING DAN APPARENT DIFFUSION COEFFICIENT DALAM MENENTUKAN DERAJAT ASTROSITOMA

Introduction: High grade astrocytomasare one of the most common primary brain tumors with overall high mortality. Magnetic resonance imaging (MRI) and apparent diffusion coefficient (ADC) could determine astrocytoma grading prior to histopathological analysis, hence patient education for treatment and prognosis could be established earlier. Aims: To obtain diagnostic value of MRI and ADC in determining grade of astrocytomas prior surgery or biopsy.
Methods: A cross-sectional research was performed using brain MRI of patients with astrocytoma as histopathological diagnosis. Astrocytoma evaluation used MRI image with Dean et al criteria and ADC measurement for all part of tumor (Ab), single (Ap) and multiple (Ar) solid part of tumor. Results: The significant determining characteristics of astrocytoma grading in MRI were border, presence of hemorrhage, and heterogeneity. The sum of astrocytoma image scoring using Dean et al criteria (cut-off value: 7) and the evaluation of astrocytoma image in MRI in determining low and high grade astrocytomas had 90.9% sensitivity and 87.5% specificity. ADC, for Ap and Ar, were significant to determine low and high grade astrocytomas with sensitivity and specificity up to 90.9% and 87.5%.
Discussions: MRI and ADC had high sensitivity and specificity to determine low and high grade astrocytomas.