Next generation sequencing as rapid diagnosis of multidrug resistance tuberculosis

Anse Diana Valentiene Messah, Jeanne Adiwinata Pawitan

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)


Multi-drug-resistant tuberculosis (MDR-TB) is a threat to global health. In 2018, TB related death was estimated to be more than 1.5 million cases worldwide. Conventional diagnostic method, which requires a long time to get a result, causes delays in new cases discoveries that lead to delayed therapy. Further, delayed and inadequate therapy causes an increase in the level of resistance to anti-TB drugs that may lead to death. Therefore, diagnostic tools, which can detect quickly and accurately, are highly needed. Early and timely detection is crucial for globally effective TB control, but this is not popular in developing countries, especially in Asia. Therefore, the objective of this review is to provide current information on the use of NGS as a rapid diagnostic tool for MDR-TB, especially in Asian populations, and to highlight the various MDR genes.

Original languageEnglish
Pages (from-to)30-37
Number of pages8
JournalAdvancements in Life Sciences
Issue number1
Publication statusPublished - 1 Nov 2020


  • Multi-Drug Resistance
  • Mycobacterium tuberculosis
  • Next Generation sequencing
  • Rapid diagnosis
  • Tuberculosis


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