TY - JOUR
T1 - Next generation sequencing as rapid diagnosis of multidrug resistance tuberculosis
AU - Messah, Anse Diana Valentiene
AU - Pawitan, Jeanne Adiwinata
N1 - Publisher Copyright:
© Advancements in Life Sciences 2020.
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Multi-drug-resistant tuberculosis (MDR-TB) is a threat to global health. In 2018, TB related death was estimated to be more than 1.5 million cases worldwide. Conventional diagnostic method, which requires a long time to get a result, causes delays in new cases discoveries that lead to delayed therapy. Further, delayed and inadequate therapy causes an increase in the level of resistance to anti-TB drugs that may lead to death. Therefore, diagnostic tools, which can detect quickly and accurately, are highly needed. Early and timely detection is crucial for globally effective TB control, but this is not popular in developing countries, especially in Asia. Therefore, the objective of this review is to provide current information on the use of NGS as a rapid diagnostic tool for MDR-TB, especially in Asian populations, and to highlight the various MDR genes.
AB - Multi-drug-resistant tuberculosis (MDR-TB) is a threat to global health. In 2018, TB related death was estimated to be more than 1.5 million cases worldwide. Conventional diagnostic method, which requires a long time to get a result, causes delays in new cases discoveries that lead to delayed therapy. Further, delayed and inadequate therapy causes an increase in the level of resistance to anti-TB drugs that may lead to death. Therefore, diagnostic tools, which can detect quickly and accurately, are highly needed. Early and timely detection is crucial for globally effective TB control, but this is not popular in developing countries, especially in Asia. Therefore, the objective of this review is to provide current information on the use of NGS as a rapid diagnostic tool for MDR-TB, especially in Asian populations, and to highlight the various MDR genes.
KW - Multi-Drug Resistance
KW - Mycobacterium tuberculosis
KW - Next Generation sequencing
KW - Rapid diagnosis
KW - Tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=85113296591&partnerID=8YFLogxK
M3 - Review article
AN - SCOPUS:85113296591
SN - 2310-5380
VL - 8
SP - 30
EP - 37
JO - Advancements in Life Sciences
JF - Advancements in Life Sciences
IS - 1
ER -