New onset bullous pemphigoid after covid-19 inactivated virus vaccination: A case report

Irene Darmawan, Lili Legiawati, Rinadewi Astriningrum, Shannaz Nadia Yusharyahya, Dina Evyana, Cinthia Christina Dewi

Research output: Contribution to journalArticlepeer-review


Bullous pemphigoid (BP) is an autoimmune bullous disease caused by circulating immunoglobulins G (IgG) against hemidesmosome antigens commonly found in elderly patients. Pemphigoid cases have been reported in association with vaccination. Cases of subepidermal blistering eruptions including BP had also been reported after COVID-19 vaccination. Here we report a case of an elderly woman who developed BP after receiving SARS-CoV-2 inactivated virus vaccine. She was presented to our hospital with a pruritic blistering eruption which started 10 days after her second dose of SARS-CoV-2 inactivated virus vaccine. She had a history of pruritic redness skin lesions on her arms and legs that appeared seven days after her first dose of vaccine. Histopathology and direct immunofluorescence examination were suggesting BP. Symptoms were improved after oral and topical corticosteroid treatment. The timeline of vaccination and appearance of blistering skin lesions suggesting possible association between BP and COVID-19 vaccination. We should be aware that the onset or flare-up of BP can occur after vaccination in the elderly.

Original languageEnglish
Pages (from-to)1771-1775
Number of pages5
JournalJournal of Pakistan Association of Dermatologists
Issue number4
Publication statusPublished - Oct 2023


  • Bullous pemphigoid
  • Covid-19 vaccination
  • Inactivated virus
  • SARS-CoV-2


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