@article{cb9e03e4ca974113998f6302abca5a02,
title = "NEW DECAHYDROACRIDINE-1,8-DIONES DERIVED FROM 3-AMINOCYCLOHEX-2-EN-1-ONE: SYNTHESIS, CHARACTERIZATION, ANTIOXIDANT, In-vitro, AND In-silico ANTI-INFLAMMATORY ACTIVITY",
abstract = "New decahydroacridine-1,8-dione derivatives have been synthesized from 3-aminocyclohex-2-en-1-one. The compounds were characterized based on spectroscopic data and assessed their antioxidant and anti-inflammatory properties both in-vitro and in-silico. All the compounds exhibited poor in-vitro antioxidant activity but high in-vitro anti-inflammatory activity. An in-silico study using Autodock v 4.2 integrated LigandScout software 4.4.3. against the COX-1 (PBD ID: 1CQE) and COX-2 (PBD ID: 6COX) enzymes indicated that all the compounds could interact with both enzymes. Except for 3c against COX-1, the compounds{\textquoteright} interaction with both enzymes exhibited binding energy lower than diclofenac and curcumin. The results confirm that the compounds have a high potential to be anti-inflammatory agents and deserve further development.",
keywords = "Acridine-1,8-dione, Anti-inflammatory, Antioxidant, Decahydroacridine-1,8-diones, In-silico, In-vitro, Synthesis",
author = "Sari, {I. P.} and H. Hariyanti and A. Yanuar and H. Hayun",
note = "Funding Information: We are full thanks to the Ministry of research and technology/NationallResearch &Innovation Agency, Indonesia, which funded this study via PDUPT Grant on 2020; No.: NKB-91/UN2.RST/HKP.05.00/2020, the Molecular Structure Analysis Lab., ITB, Indonesia, and the Chemical Research Center, LIPI, Indonesia, measured NMR spectra and mass spectra. Funding Information: We are full thanks to the Ministry of research and technology/NationallResearch &&Innovation Agency, Indonesia, which funded this study via PDUPT Grant on 2020; No.: NKB-91/UN2.RST/HKP.05.00/2020, theMolecularStructureAnalysisLab.,ITB,Indonesia,andtheChemicalResearchCenter, LIPI,Indonesia, measured NMR spectra and mass spectra. Publisher Copyright: {\textcopyright} 2022, Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma. All rights reserved.",
year = "2022",
month = apr,
day = "1",
doi = "10.31788/RJC.1526775",
language = "English",
volume = "15",
pages = "1241--1248",
journal = "Rasayan Journal of Chemistry",
issn = "0974-1496",
publisher = "Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma",
number = "2",
}