New cytotoxic compounds from Myristica fatua Houtt leaves against MCF-7 cell lines

Sofa Fajriah; Akhmad Darmawan; Megawati; Sumi Hudiyono; Soleh Kosela; Muhammad Hanafi

doi:10.1016/j.phytol.2017.03.013

New cytotoxic compounds from Myristica fatua Houtt leaves against MCF-7 cell lines

Sofa Fajriah
, Akhmad Darmawan
, Megawati
, Sumi Hudiyono
, Soleh Kosela
, Muhammad Hanafi

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Two novel compounds, (7S, 8R, 8′S, 7′S) 7,7′-bis(3-hydroxy-5-methoxyphenyl)-8,8′-dimethylbuthane-7,7′-diol, and 3”-hydroxydemethyldactyloidin were isolated from the leaves of Myristica fatua Houtt, and their structures were determined using spectroscopic techniques, including 2D NMR. Both compounds showed in vitro cytotoxic activity against the breast cancer cell line MCF-7, with IC₅₀ of 26.19 and 8.33 μM, respectively.

Original language	English
Pages (from-to)	36-39
Number of pages	4
Journal	Phytochemistry Letters
Volume	20
DOIs	https://doi.org/10.1016/j.phytol.2017.03.013
Publication status	Published - 1 Jun 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

(7S, 8R, 8′S, 7′S) 7,7′-bis(3-hydroxy-5-methoxyphenyl)-8,8′-dimethylbuthane-7,7′-diol
3”-Hydroxydemethyldactyloidin
Cytotoxic activity
MCF-7
Myristica fatua Houtt

Access to Document

10.1016/j.phytol.2017.03.013

Cite this

@article{51d1b993863c45f8a62e8f392f64ef56,

title = "New cytotoxic compounds from Myristica fatua Houtt leaves against MCF-7 cell lines",

abstract = "Two novel compounds, (7S, 8R, 8′S, 7′S) 7,7′-bis(3-hydroxy-5-methoxyphenyl)-8,8′-dimethylbuthane-7,7′-diol, and 3”-hydroxydemethyldactyloidin were isolated from the leaves of Myristica fatua Houtt, and their structures were determined using spectroscopic techniques, including 2D NMR. Both compounds showed in vitro cytotoxic activity against the breast cancer cell line MCF-7, with IC50 of 26.19 and 8.33 μM, respectively.",

keywords = "(7S, 8R, 8′S, 7′S) 7,7′-bis(3-hydroxy-5-methoxyphenyl)-8,8′-dimethylbuthane-7,7′-diol, 3”-Hydroxydemethyldactyloidin, Cytotoxic activity, MCF-7, Myristica fatua Houtt",

author = "Sofa Fajriah and Akhmad Darmawan and Megawati and Sumi Hudiyono and Soleh Kosela and Muhammad Hanafi",

note = "Publisher Copyright: {\textcopyright} 2017 Phytochemical Society of Europe",

year = "2017",

month = jun,

day = "1",

doi = "10.1016/j.phytol.2017.03.013",

language = "English",

volume = "20",

pages = "36--39",

journal = "Phytochemistry Letters",

issn = "1874-3900",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - New cytotoxic compounds from Myristica fatua Houtt leaves against MCF-7 cell lines

AU - Fajriah, Sofa

AU - Darmawan, Akhmad

AU - Megawati,

AU - Hudiyono, Sumi

AU - Kosela, Soleh

AU - Hanafi, Muhammad

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Two novel compounds, (7S, 8R, 8′S, 7′S) 7,7′-bis(3-hydroxy-5-methoxyphenyl)-8,8′-dimethylbuthane-7,7′-diol, and 3”-hydroxydemethyldactyloidin were isolated from the leaves of Myristica fatua Houtt, and their structures were determined using spectroscopic techniques, including 2D NMR. Both compounds showed in vitro cytotoxic activity against the breast cancer cell line MCF-7, with IC50 of 26.19 and 8.33 μM, respectively.

AB - Two novel compounds, (7S, 8R, 8′S, 7′S) 7,7′-bis(3-hydroxy-5-methoxyphenyl)-8,8′-dimethylbuthane-7,7′-diol, and 3”-hydroxydemethyldactyloidin were isolated from the leaves of Myristica fatua Houtt, and their structures were determined using spectroscopic techniques, including 2D NMR. Both compounds showed in vitro cytotoxic activity against the breast cancer cell line MCF-7, with IC50 of 26.19 and 8.33 μM, respectively.

KW - (7S, 8R, 8′S, 7′S) 7,7′-bis(3-hydroxy-5-methoxyphenyl)-8,8′-dimethylbuthane-7,7′-diol

KW - 3”-Hydroxydemethyldactyloidin

KW - Cytotoxic activity

KW - MCF-7

KW - Myristica fatua Houtt

UR - https://www.scopus.com/pages/publications/85017251942

U2 - 10.1016/j.phytol.2017.03.013

DO - 10.1016/j.phytol.2017.03.013

M3 - Article

AN - SCOPUS:85017251942

SN - 1874-3900

VL - 20

SP - 36

EP - 39

JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

New cytotoxic compounds from Myristica fatua Houtt leaves against MCF-7 cell lines

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this