TY - JOUR
T1 - New cytotoxic compounds from Myristica fatua Houtt leaves against MCF-7 cell lines
AU - Fajriah, Sofa
AU - Darmawan, Akhmad
AU - Megawati,
AU - Pws, Sumi Hudiyono
AU - Kosela, Soleh
AU - Hanafi, Muhammad
N1 - Publisher Copyright:
© 2017 Phytochemical Society of Europe
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Two novel compounds, (7S, 8R, 8′S, 7′S) 7,7′-bis(3-hydroxy-5-methoxyphenyl)-8,8′-dimethylbuthane-7,7′-diol, and 3”-hydroxydemethyldactyloidin were isolated from the leaves of Myristica fatua Houtt, and their structures were determined using spectroscopic techniques, including 2D NMR. Both compounds showed in vitro cytotoxic activity against the breast cancer cell line MCF-7, with IC50 of 26.19 and 8.33 μM, respectively.
AB - Two novel compounds, (7S, 8R, 8′S, 7′S) 7,7′-bis(3-hydroxy-5-methoxyphenyl)-8,8′-dimethylbuthane-7,7′-diol, and 3”-hydroxydemethyldactyloidin were isolated from the leaves of Myristica fatua Houtt, and their structures were determined using spectroscopic techniques, including 2D NMR. Both compounds showed in vitro cytotoxic activity against the breast cancer cell line MCF-7, with IC50 of 26.19 and 8.33 μM, respectively.
KW - (7S, 8R, 8′S, 7′S) 7,7′-bis(3-hydroxy-5-methoxyphenyl)-8,8′-dimethylbuthane-7,7′-diol
KW - 3”-Hydroxydemethyldactyloidin
KW - Cytotoxic activity
KW - MCF-7
KW - Myristica fatua Houtt
UR - http://www.scopus.com/inward/record.url?scp=85017251942&partnerID=8YFLogxK
U2 - 10.1016/j.phytol.2017.03.013
DO - 10.1016/j.phytol.2017.03.013
M3 - Article
AN - SCOPUS:85017251942
SN - 1874-3900
VL - 20
SP - 36
EP - 39
JO - Phytochemistry Letters
JF - Phytochemistry Letters
ER -