New cytotoxic compounds from Myristica fatua Houtt leaves against MCF-7 cell lines

Sofa Fajriah, Akhmad Darmawan, Megawati, Sumi Hudiyono Pws, Soleh Kosela, Muhammad Hanafi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Two novel compounds, (7S, 8R, 8′S, 7′S) 7,7′-bis(3-hydroxy-5-methoxyphenyl)-8,8′-dimethylbuthane-7,7′-diol, and 3”-hydroxydemethyldactyloidin were isolated from the leaves of Myristica fatua Houtt, and their structures were determined using spectroscopic techniques, including 2D NMR. Both compounds showed in vitro cytotoxic activity against the breast cancer cell line MCF-7, with IC50 of 26.19 and 8.33 μM, respectively.

Original languageEnglish
Pages (from-to)36-39
Number of pages4
JournalPhytochemistry Letters
Volume20
DOIs
Publication statusPublished - 1 Jun 2017

Keywords

  • (7S, 8R, 8′S, 7′S) 7,7′-bis(3-hydroxy-5-methoxyphenyl)-8,8′-dimethylbuthane-7,7′-diol
  • 3”-Hydroxydemethyldactyloidin
  • Cytotoxic activity
  • MCF-7
  • Myristica fatua Houtt

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