TY - JOUR
T1 - New compound from the plant origin of propolis from Lombok, Indonesia and its antibacterial activity
AU - Mizuno, Sayaka
AU - Miyata, Ryo
AU - Mukaide, Kazuma
AU - Honda, Sari
AU - Sukito, Agus
AU - Sahlan, Muhamad
AU - Taniguchi, Tohru
AU - Kumazawa, Shigenori
N1 - Funding Information:
The authors would like to thank Professor Shuichi Masuda and Dr. Yuko Shimamura for their cooperation with the antibacterial assay. The authors thank the JSPS KAKENHI JP18KK0165 and JP20J23632 for generous grants.
Publisher Copyright:
© 2022 The Authors
PY - 2022/1
Y1 - 2022/1
N2 - We revealed the plant origin of propolis from Lombok, Indonesia; its plant origin was Calophyllum inophyllum Linn. This was confirmed by observing the behavior of stingless bees and from the LC-MS analysis of the 70% ethanol extracts of the propolis and C. inophyllum resin. Furthermore, a new chromanone derivative, calophylloidic acid A (1), was isolated from the stem bark resin of C. inophyllum. The structure of 1 was elucidated using a combination method based on the IR, UV, HRESIMS, and 1D and 2D NMR analyses. The absolute structure of C-2 and C-3 positions of 1 was determined by electronic circular dichroism (ECD). This determination was supported by the time-dependent density functional theory (TD-DFT) and ECD calculations. Additionally, the C. inophyllum resin, propolis, and 1 exhibited significant antibacterial activity against Staphylococcus aureus and Escherichia coli.
AB - We revealed the plant origin of propolis from Lombok, Indonesia; its plant origin was Calophyllum inophyllum Linn. This was confirmed by observing the behavior of stingless bees and from the LC-MS analysis of the 70% ethanol extracts of the propolis and C. inophyllum resin. Furthermore, a new chromanone derivative, calophylloidic acid A (1), was isolated from the stem bark resin of C. inophyllum. The structure of 1 was elucidated using a combination method based on the IR, UV, HRESIMS, and 1D and 2D NMR analyses. The absolute structure of C-2 and C-3 positions of 1 was determined by electronic circular dichroism (ECD). This determination was supported by the time-dependent density functional theory (TD-DFT) and ECD calculations. Additionally, the C. inophyllum resin, propolis, and 1 exhibited significant antibacterial activity against Staphylococcus aureus and Escherichia coli.
KW - Calophylloidic acid A
KW - Calophyllum inophyllum
KW - Chromanone
KW - Indonesia
KW - Propolis
UR - http://www.scopus.com/inward/record.url?scp=85122630131&partnerID=8YFLogxK
U2 - 10.1016/j.rechem.2021.100276
DO - 10.1016/j.rechem.2021.100276
M3 - Article
AN - SCOPUS:85122630131
SN - 2211-7156
VL - 4
JO - Results in Chemistry
JF - Results in Chemistry
M1 - 100276
ER -