New 9-Thiocyanatopupukeanane Sesquiterpenes from the Nudibranch Phyllidia varicosa and Its Sponge-Prey Axinyssa aculeata

Ru Angelie Edrada; Victor Wray; Peter Proksch

New 9-Thiocyanatopupukeanane Sesquiterpenes from the Nudibranch Phyllidia varicosa and Its Sponge-Prey Axinyssa aculeata

Yasman, Ru Angelie Edrada, Victor Wray, Peter Proksch

Department of Biology

Research output: Contribution to journal › Article › peer-review

81 Citations (Scopus)

Abstract

Two new 9-thiocyanatopupukeanane sesquiterpene isomers were isolated as major metabolites from the MeOH extract of the sponge Axinyssa aculeata and from its nudibranch predator Phyllidia varicosa. The presence of the sesquiterpenes was monitored by GC-MS, and the structures were confirmed by both 1D and 2D NMR spectroscopy. The isolated sesquiterpenes were found to be toxic toward brine shrimp at LC₅₀ of 5 ppm. At a dose level of 20 μg, they were found to be weakly and moderately active against B. subtilis and C. albicans, respectively.

Original language	English
Pages (from-to)	1512-1514
Number of pages	3
Journal	Journal of Natural Products
Volume	66
Issue number	11
Publication status	Published - 1 Nov 2003

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title = "New 9-Thiocyanatopupukeanane Sesquiterpenes from the Nudibranch Phyllidia varicosa and Its Sponge-Prey Axinyssa aculeata",

abstract = "Two new 9-thiocyanatopupukeanane sesquiterpene isomers were isolated as major metabolites from the MeOH extract of the sponge Axinyssa aculeata and from its nudibranch predator Phyllidia varicosa. The presence of the sesquiterpenes was monitored by GC-MS, and the structures were confirmed by both 1D and 2D NMR spectroscopy. The isolated sesquiterpenes were found to be toxic toward brine shrimp at LC50 of 5 ppm. At a dose level of 20 μg, they were found to be weakly and moderately active against B. subtilis and C. albicans, respectively.",

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T1 - New 9-Thiocyanatopupukeanane Sesquiterpenes from the Nudibranch Phyllidia varicosa and Its Sponge-Prey Axinyssa aculeata

AU - Yasman, null

AU - Edrada, Ru Angelie

AU - Wray, Victor

AU - Proksch, Peter

PY - 2003/11/1

Y1 - 2003/11/1

N2 - Two new 9-thiocyanatopupukeanane sesquiterpene isomers were isolated as major metabolites from the MeOH extract of the sponge Axinyssa aculeata and from its nudibranch predator Phyllidia varicosa. The presence of the sesquiterpenes was monitored by GC-MS, and the structures were confirmed by both 1D and 2D NMR spectroscopy. The isolated sesquiterpenes were found to be toxic toward brine shrimp at LC50 of 5 ppm. At a dose level of 20 μg, they were found to be weakly and moderately active against B. subtilis and C. albicans, respectively.

AB - Two new 9-thiocyanatopupukeanane sesquiterpene isomers were isolated as major metabolites from the MeOH extract of the sponge Axinyssa aculeata and from its nudibranch predator Phyllidia varicosa. The presence of the sesquiterpenes was monitored by GC-MS, and the structures were confirmed by both 1D and 2D NMR spectroscopy. The isolated sesquiterpenes were found to be toxic toward brine shrimp at LC50 of 5 ppm. At a dose level of 20 μg, they were found to be weakly and moderately active against B. subtilis and C. albicans, respectively.

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JO - Journal of Natural Products

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SN - 0163-3864

IS - 11

ER -

New 9-Thiocyanatopupukeanane Sesquiterpenes from the Nudibranch Phyllidia varicosa and Its Sponge-Prey Axinyssa aculeata

Abstract

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