New 9-Thiocyanatopupukeanane Sesquiterpenes from the Nudibranch Phyllidia varicosa and Its Sponge-Prey Axinyssa aculeata

Ru Angelie Edrada; Victor Wray; Peter Proksch

doi:10.1021/np030237j

New 9-Thiocyanatopupukeanane Sesquiterpenes from the Nudibranch Phyllidia varicosa and Its Sponge-Prey Axinyssa aculeata

Yasman, Ru Angelie Edrada, Victor Wray, Peter Proksch

Department of Biology

Research output: Contribution to journal › Article › peer-review

89 Citations (Scopus)

Abstract

Two new 9-thiocyanatopupukeanane sesquiterpene isomers were isolated as major metabolites from the MeOH extract of the sponge Axinyssa aculeata and from its nudibranch predator Phyllidia varicosa. The presence of the sesquiterpenes was monitored by GC-MS, and the structures were confirmed by both 1D and 2D NMR spectroscopy. The isolated sesquiterpenes were found to be toxic toward brine shrimp at LC₅₀ of 5 ppm. At a dose level of 20 μg, they were found to be weakly and moderately active against B. subtilis and C. albicans, respectively.

Original language	English
Pages (from-to)	1512-1514
Number of pages	3
Journal	Journal of Natural Products
Volume	66
Issue number	11
DOIs	https://doi.org/10.1021/np030237j
Publication status	Published - Nov 2003

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10.1021/np030237j

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abstract = "Two new 9-thiocyanatopupukeanane sesquiterpene isomers were isolated as major metabolites from the MeOH extract of the sponge Axinyssa aculeata and from its nudibranch predator Phyllidia varicosa. The presence of the sesquiterpenes was monitored by GC-MS, and the structures were confirmed by both 1D and 2D NMR spectroscopy. The isolated sesquiterpenes were found to be toxic toward brine shrimp at LC50 of 5 ppm. At a dose level of 20 μg, they were found to be weakly and moderately active against B. subtilis and C. albicans, respectively.",

author = "Yasman and Edrada, {Ru Angelie} and Victor Wray and Peter Proksch",

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AU - Edrada, Ru Angelie

AU - Wray, Victor

AU - Proksch, Peter

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AB - Two new 9-thiocyanatopupukeanane sesquiterpene isomers were isolated as major metabolites from the MeOH extract of the sponge Axinyssa aculeata and from its nudibranch predator Phyllidia varicosa. The presence of the sesquiterpenes was monitored by GC-MS, and the structures were confirmed by both 1D and 2D NMR spectroscopy. The isolated sesquiterpenes were found to be toxic toward brine shrimp at LC50 of 5 ppm. At a dose level of 20 μg, they were found to be weakly and moderately active against B. subtilis and C. albicans, respectively.

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ER -

New 9-Thiocyanatopupukeanane Sesquiterpenes from the Nudibranch Phyllidia varicosa and Its Sponge-Prey Axinyssa aculeata

Abstract

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