Neuromyelitis optic with positive Anti-AQP4 and Anti-SSA/Ro antibody

Riwanti Estiasari; Salsabila Firdausia; Dewi Wulandari; Kartika Maharani; Freddy Sitorus; David Pangeran; Darma Imran

doi:10.4081/ni.2019.7958

Neuromyelitis optic with positive Anti-AQP4 and Anti-SSA/Ro antibody

Riwanti Estiasari, Salsabila Firdausia, Dewi Wulandari, Kartika Maharani, Freddy Sitorus, David Pangeran, Darma Imran

Research output: Contribution to journal › Article › peer-review

Abstract

Neuromyelitis Optic (NMO) is an inflammatory disorder involving central nervous system which often co-exists with other autoimmune diseases such as Sjögren’s syndrome (SS). NMO manifestation could precede or follow SS, but the role of anti-SSA in the pathogenesis of NMO remains unclear. We present a case of NMO with anti-AQP4 anti-SSA antibody positive. A-44-year-old female presented with right side weakness. The symptoms began with numbness that improved spontaneously. She also complained pain and dry sensations on her eyes. Schirmer test on her left eye, antinuclear antibody (ANA) and anti- SSA antibody were positive. Cervical MRI revealed intramedullary lesion on T2- weighted-image at C2-C5 level. She was diagnosed as NMO with positive anti- AQP4 and probable SS. She received 1g methylprednisolone for 5 days proceeded with mycophenolic acid. One-year observation showed clinical improvement. Systemic autoantibodies must substantially be evaluated in NMO. Comprehensive diagnosis and providing appropriate immunosuppressant might prevent further disability and relapse.

Original language	English
Article number	7958
Pages (from-to)	1-3
Number of pages	3
Journal	Neurology International
Volume	11
Issue number	1
DOIs	https://doi.org/10.4081/ni.2019.7958
Publication status	Published - 11 Mar 2019

Keywords

Anti-SSA
AQP4
Neuromyelitis optic
Sjogren

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title = "Neuromyelitis optic with positive Anti-AQP4 and Anti-SSA/Ro antibody",

abstract = "Neuromyelitis Optic (NMO) is an inflammatory disorder involving central nervous system which often co-exists with other autoimmune diseases such as Sj{\"o}gren{\textquoteright}s syndrome (SS). NMO manifestation could precede or follow SS, but the role of anti-SSA in the pathogenesis of NMO remains unclear. We present a case of NMO with anti-AQP4 anti-SSA antibody positive. A-44-year-old female presented with right side weakness. The symptoms began with numbness that improved spontaneously. She also complained pain and dry sensations on her eyes. Schirmer test on her left eye, antinuclear antibody (ANA) and anti- SSA antibody were positive. Cervical MRI revealed intramedullary lesion on T2- weighted-image at C2-C5 level. She was diagnosed as NMO with positive anti- AQP4 and probable SS. She received 1g methylprednisolone for 5 days proceeded with mycophenolic acid. One-year observation showed clinical improvement. Systemic autoantibodies must substantially be evaluated in NMO. Comprehensive diagnosis and providing appropriate immunosuppressant might prevent further disability and relapse.",

keywords = "Anti-SSA, AQP4, Neuromyelitis optic, Sjogren",

author = "Riwanti Estiasari and Salsabila Firdausia and Dewi Wulandari and Kartika Maharani and Freddy Sitorus and David Pangeran and Darma Imran",

note = "Funding Information: Funding: This report is supported by Hibah Pitta 2018 (PITTA/694/FK/2018) funded by DRPM Universitas Indonesia. Publisher Copyright: {\textcopyright} R. Estiasari et al., 2019.",

year = "2019",

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doi = "10.4081/ni.2019.7958",

language = "English",

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T1 - Neuromyelitis optic with positive Anti-AQP4 and Anti-SSA/Ro antibody

AU - Estiasari, Riwanti

AU - Firdausia, Salsabila

AU - Wulandari, Dewi

AU - Maharani, Kartika

AU - Sitorus, Freddy

AU - Pangeran, David

AU - Imran, Darma

N1 - Funding Information: Funding: This report is supported by Hibah Pitta 2018 (PITTA/694/FK/2018) funded by DRPM Universitas Indonesia. Publisher Copyright: © R. Estiasari et al., 2019.

PY - 2019/3/11

Y1 - 2019/3/11

N2 - Neuromyelitis Optic (NMO) is an inflammatory disorder involving central nervous system which often co-exists with other autoimmune diseases such as Sjögren’s syndrome (SS). NMO manifestation could precede or follow SS, but the role of anti-SSA in the pathogenesis of NMO remains unclear. We present a case of NMO with anti-AQP4 anti-SSA antibody positive. A-44-year-old female presented with right side weakness. The symptoms began with numbness that improved spontaneously. She also complained pain and dry sensations on her eyes. Schirmer test on her left eye, antinuclear antibody (ANA) and anti- SSA antibody were positive. Cervical MRI revealed intramedullary lesion on T2- weighted-image at C2-C5 level. She was diagnosed as NMO with positive anti- AQP4 and probable SS. She received 1g methylprednisolone for 5 days proceeded with mycophenolic acid. One-year observation showed clinical improvement. Systemic autoantibodies must substantially be evaluated in NMO. Comprehensive diagnosis and providing appropriate immunosuppressant might prevent further disability and relapse.

AB - Neuromyelitis Optic (NMO) is an inflammatory disorder involving central nervous system which often co-exists with other autoimmune diseases such as Sjögren’s syndrome (SS). NMO manifestation could precede or follow SS, but the role of anti-SSA in the pathogenesis of NMO remains unclear. We present a case of NMO with anti-AQP4 anti-SSA antibody positive. A-44-year-old female presented with right side weakness. The symptoms began with numbness that improved spontaneously. She also complained pain and dry sensations on her eyes. Schirmer test on her left eye, antinuclear antibody (ANA) and anti- SSA antibody were positive. Cervical MRI revealed intramedullary lesion on T2- weighted-image at C2-C5 level. She was diagnosed as NMO with positive anti- AQP4 and probable SS. She received 1g methylprednisolone for 5 days proceeded with mycophenolic acid. One-year observation showed clinical improvement. Systemic autoantibodies must substantially be evaluated in NMO. Comprehensive diagnosis and providing appropriate immunosuppressant might prevent further disability and relapse.

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Neuromyelitis optic with positive Anti-AQP4 and Anti-SSA/Ro antibody

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Keywords

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