TY - JOUR
T1 - Neurological Disease Associated with Chikungunya in Indonesia
AU - Myint, Khin S.A.
AU - Mawuntu, Arthur H.P.
AU - Haryanto, Sotianingsih
AU - Imran, Darma
AU - Dian, Sofiati
AU - Dewi, Yora P.
AU - Ganiem, Ahmad R.
AU - Anggreani, Riane
AU - Iskandar, Mirna M.
AU - Bernadus, Janno B.B.
AU - Maharani, Kartika
AU - Susanto, David
AU - Estiasari, Riwanti
AU - Dewi, Hasna
AU - Kristiani, Amanda
AU - Gaghiwu, Lidia
AU - Johar, Edison
AU - Yudhaputri, Frilasita A.
AU - Antonjaya, Ungke
AU - Ledermann, Jeremy P.
AU - van Crevel, Reinout
AU - Hamers, Raph L.
AU - Powers, Ann M.
N1 - Funding Information:
Financial support: This work was supported by the Ministry of Research and Technology, Republic of Indonesia; Sam Ratulangi University Medical Faculty; Faculty of Medicine and Health Sciences, Universitas Jambi; and the U.S. Centers for Disease Control and Prevention. The Indonesia Brain Infection Study received support from the U.S. National Institutes of Health through the ULTIMATE project (Grant no. R01AI145781). RLH is supported by the Wellcome Trust.
Publisher Copyright:
Copyright © 2022 The American Society of Tropical Medicine and Hygiene.
PY - 2022/8
Y1 - 2022/8
N2 - Chikungunya virus (CHIKV) is recognized but rarely considered as a cause of central nervous system infection in endemic areas. A total of 244 patients with acute meningoencephalitis in Indonesia were retrospectively tested to identify whether any CHIKV infection was associated with neurological manifestations, especially in provinces known for CHIKV endemicity. Cerebrospinal fluid (CSF) and blood specimens were tested using CHIKV-specific real-time reverse transcription polymerase chain reaction and IgM ELISA, alongside a panel of neurotropic viruses. We report four cases of suspected or confirmed CHIKV-associated neurological disease, including CHIKV RNA detection in CSF of one patient and in acute serum of another, and CHIKV IgM in CSF of three patients and in serum of a fourth. In conclusion, CHIKV should be considered as a cause of neurologic disease in endemic areas and especially during outbreaks, in addition to the more common arboviral diseases such as dengue and Japanese encephalitis viruses.
AB - Chikungunya virus (CHIKV) is recognized but rarely considered as a cause of central nervous system infection in endemic areas. A total of 244 patients with acute meningoencephalitis in Indonesia were retrospectively tested to identify whether any CHIKV infection was associated with neurological manifestations, especially in provinces known for CHIKV endemicity. Cerebrospinal fluid (CSF) and blood specimens were tested using CHIKV-specific real-time reverse transcription polymerase chain reaction and IgM ELISA, alongside a panel of neurotropic viruses. We report four cases of suspected or confirmed CHIKV-associated neurological disease, including CHIKV RNA detection in CSF of one patient and in acute serum of another, and CHIKV IgM in CSF of three patients and in serum of a fourth. In conclusion, CHIKV should be considered as a cause of neurologic disease in endemic areas and especially during outbreaks, in addition to the more common arboviral diseases such as dengue and Japanese encephalitis viruses.
UR - http://www.scopus.com/inward/record.url?scp=85137406295&partnerID=8YFLogxK
U2 - 10.4269/ajtmh.22-0050
DO - 10.4269/ajtmh.22-0050
M3 - Article
C2 - 35895435
AN - SCOPUS:85137406295
SN - 0002-9637
VL - 107
SP - 291
EP - 295
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 2
ER -
