TY - JOUR
T1 - Nephroprotective effect of Pterocarpus indicus Willd. Leaves
T2 - Observation of Urine Volume, Sodium and Potassium Levels in Gentamicin-induced Rat Model
AU - Saputri, Fadlina Chany
AU - Adiyati, Zahra
AU - Waty, Desy Rasta
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Introduction: Kidney disease is a common disease worldwide. The leaves from Pterocarpus indicus Willd. is alternatively applied for prevention therapy of patients with kidney diseases. Objective: The aim of this study to demonstrate the scientific nephroprotective effect of water-boiled P. indicus leaves evaluated from urine volume, sodium and potassium levels. Materials and Methods: Thirty male Sprague-Dawley rats were divided into five treatment groups; group I (control), group II (gentamicin-induced 80 mg/kg i.p from day 15 to 21), and group III to V (induced; variated doses respectively 28.8 mg/kg; 57,6 mg/kg; and 115,2 mg/kg bw which was given for 21 days orally as single doses). Nephroprotective effects were observed as abnormal from levels of urinary volume. Results: Obtained results on sodium and potassium levels show the group given the highest dose (115,2 mg/kg) resulted in decreased sodium levels and increased levels of urinary potassium as well as having a significant difference (p<0,05) to the induction group. Observed 24-hour urine volume, however, did not show any significant signs of nephroprotective effects. Conclusion: It can be concluded that the leaves of P. indicus have potential nephroprotective properties.
AB - Introduction: Kidney disease is a common disease worldwide. The leaves from Pterocarpus indicus Willd. is alternatively applied for prevention therapy of patients with kidney diseases. Objective: The aim of this study to demonstrate the scientific nephroprotective effect of water-boiled P. indicus leaves evaluated from urine volume, sodium and potassium levels. Materials and Methods: Thirty male Sprague-Dawley rats were divided into five treatment groups; group I (control), group II (gentamicin-induced 80 mg/kg i.p from day 15 to 21), and group III to V (induced; variated doses respectively 28.8 mg/kg; 57,6 mg/kg; and 115,2 mg/kg bw which was given for 21 days orally as single doses). Nephroprotective effects were observed as abnormal from levels of urinary volume. Results: Obtained results on sodium and potassium levels show the group given the highest dose (115,2 mg/kg) resulted in decreased sodium levels and increased levels of urinary potassium as well as having a significant difference (p<0,05) to the induction group. Observed 24-hour urine volume, however, did not show any significant signs of nephroprotective effects. Conclusion: It can be concluded that the leaves of P. indicus have potential nephroprotective properties.
KW - Gentamicin
KW - Nephroprotective
KW - Potassium
KW - Pterocarpus indicus
KW - Sodium
KW - Urine volume
UR - http://www.scopus.com/inward/record.url?scp=85017021572&partnerID=8YFLogxK
U2 - 10.5530/jyp.2017.1s.21
DO - 10.5530/jyp.2017.1s.21
M3 - Article
AN - SCOPUS:85017021572
SN - 0975-1483
VL - 9
SP - S85-S88
JO - Journal of Young Pharmacists
JF - Journal of Young Pharmacists
IS - 1
ER -