Neonatal Jaundice in Low- and Middle-Income Countries: Lessons and Future Directions from the 2015 Don Ostrow Trieste Yellow Retreat

Chiara Greco, Gaston Arnolda, Nem Yun Boo, Iman F. Iskander, Angela A. Okolo, Rinawati Rohsiswatmo, Steven M. Shapiro, Jon Watchko, Richard P. Wennberg, Claudio Tiribelli, Carlos D. Coda Zabetta

Research output: Contribution to journalReview articlepeer-review

65 Citations (Scopus)

Abstract

Severe neonatal hyperbilirubinemia, defined as total serum bilirubin (TSB) ≥20 mg/dl, is associated with a higher risk of permanent neurological sequelae and death. Jaundice can and should be promptly diagnosed and treated. Reliable methods for TSB assay are not always readily available, particularly in low- and middle-income countries, making the true incidence of severe neonatal jaundice (NNJ) difficult to estimate. To gather a more comprehensive picture, a symposium addressing NNJ worldwide was organized during the 2015 Don Ostrow Trieste Yellow Retreat. Data collected by several researchers in different regions of the world were presented and differences/similarities discussed. This report points out the need for: (1) a coordinated worldwide effort to define the burden and the causes of severe NNJ and its consequences; (2) aggressive educational programs for families and health personnel to facilitate timely care-seeking, and (3) accurate diagnostics and effective phototherapy.

Original languageEnglish
Pages (from-to)172-180
Number of pages9
JournalNeonatology
Volume110
Issue number3
DOIs
Publication statusPublished - 1 Sep 2016

Keywords

  • Acute bilirubin encephalopathy
  • Kernicterus
  • Low- and middle-income countries
  • Neonatal jaundice
  • Severe hyperbilirubinemia

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