Natural killer cell neoplasm: Biology and pathology

Maria Francisca Ham; Young Hyeh Ko

doi:10.1007/s12185-010-0738-y

Natural killer cell neoplasm: Biology and pathology

Maria Francisca Ham
, Young Hyeh Ko

Department of Pathological Anatomy

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Natural killer (NK) cell neoplasm is a heterogeneous disease group. In the latest World Health Organization (WHO) classification of tumours of hematopoietic and lymphoid tissues (2008), disease entities considered as NK-cell derivation include NK-lymphoblastic leukemia/lymphoma, chronic lymphoproliferative disorders of NK cells, aggressive NK-cell leukemia, and extranodal NK-cell lymphoma, nasal-type. Despite recent advances in NK-cell research, which have expanded our understanding of the biology of NK-cell neoplasm, it cannot yet be sharply delineated from myeloid neoplasms and T-cell neoplasms even in some "well-known" entity, such as extranodal NK/T-cell lymphoma. This review describes current knowledge of the biology of NK cells and pathology of NK neoplasms as classified in the 2008 WHO classification of tumours of hematopoietic and lymphoid tissues.

Original language	English
Pages (from-to)	681-689
Number of pages	9
Journal	International journal of hematology
Volume	92
Issue number	5
DOIs	https://doi.org/10.1007/s12185-010-0738-y
Publication status	Published - Dec 2010

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Biology
Cell
Lymphoma
NK
Pathology

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10.1007/s12185-010-0738-y

Cite this

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title = "Natural killer cell neoplasm: Biology and pathology",

abstract = "Natural killer (NK) cell neoplasm is a heterogeneous disease group. In the latest World Health Organization (WHO) classification of tumours of hematopoietic and lymphoid tissues (2008), disease entities considered as NK-cell derivation include NK-lymphoblastic leukemia/lymphoma, chronic lymphoproliferative disorders of NK cells, aggressive NK-cell leukemia, and extranodal NK-cell lymphoma, nasal-type. Despite recent advances in NK-cell research, which have expanded our understanding of the biology of NK-cell neoplasm, it cannot yet be sharply delineated from myeloid neoplasms and T-cell neoplasms even in some {"}well-known{"} entity, such as extranodal NK/T-cell lymphoma. This review describes current knowledge of the biology of NK cells and pathology of NK neoplasms as classified in the 2008 WHO classification of tumours of hematopoietic and lymphoid tissues.",

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author = "Ham, \{Maria Francisca\} and Ko, \{Young Hyeh\}",

note = "Funding Information: Acknowledgments This work was supported by the Samsung Biomedical Research Institute Grant, \#SBRI C-A8-202, Korea Healthcare Technology R\&D Project, Ministry for Health and Welfare, Republic of Korea (A092255).",

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doi = "10.1007/s12185-010-0738-y",

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pages = "681--689",

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T2 - Biology and pathology

AU - Ham, Maria Francisca

AU - Ko, Young Hyeh

N1 - Funding Information: Acknowledgments This work was supported by the Samsung Biomedical Research Institute Grant, #SBRI C-A8-202, Korea Healthcare Technology R&D Project, Ministry for Health and Welfare, Republic of Korea (A092255).

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Y1 - 2010/12

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AB - Natural killer (NK) cell neoplasm is a heterogeneous disease group. In the latest World Health Organization (WHO) classification of tumours of hematopoietic and lymphoid tissues (2008), disease entities considered as NK-cell derivation include NK-lymphoblastic leukemia/lymphoma, chronic lymphoproliferative disorders of NK cells, aggressive NK-cell leukemia, and extranodal NK-cell lymphoma, nasal-type. Despite recent advances in NK-cell research, which have expanded our understanding of the biology of NK-cell neoplasm, it cannot yet be sharply delineated from myeloid neoplasms and T-cell neoplasms even in some "well-known" entity, such as extranodal NK/T-cell lymphoma. This review describes current knowledge of the biology of NK cells and pathology of NK neoplasms as classified in the 2008 WHO classification of tumours of hematopoietic and lymphoid tissues.

KW - Biology

KW - Cell

KW - Lymphoma

KW - NK

KW - Pathology

UR - https://www.scopus.com/pages/publications/78751585023

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DO - 10.1007/s12185-010-0738-y

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JO - International journal of hematology

JF - International journal of hematology

IS - 5

ER -

Natural killer cell neoplasm: Biology and pathology

Abstract

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Keywords

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