TY - JOUR
T1 - Natural killer cell neoplasm
T2 - Biology and pathology
AU - Ham, Maria Francisca
AU - Ko, Young Hyeh
N1 - Funding Information:
Acknowledgments This work was supported by the Samsung Biomedical Research Institute Grant, #SBRI C-A8-202, Korea Healthcare Technology R&D Project, Ministry for Health and Welfare, Republic of Korea (A092255).
PY - 2010/12
Y1 - 2010/12
N2 - Natural killer (NK) cell neoplasm is a heterogeneous disease group. In the latest World Health Organization (WHO) classification of tumours of hematopoietic and lymphoid tissues (2008), disease entities considered as NK-cell derivation include NK-lymphoblastic leukemia/lymphoma, chronic lymphoproliferative disorders of NK cells, aggressive NK-cell leukemia, and extranodal NK-cell lymphoma, nasal-type. Despite recent advances in NK-cell research, which have expanded our understanding of the biology of NK-cell neoplasm, it cannot yet be sharply delineated from myeloid neoplasms and T-cell neoplasms even in some "well-known" entity, such as extranodal NK/T-cell lymphoma. This review describes current knowledge of the biology of NK cells and pathology of NK neoplasms as classified in the 2008 WHO classification of tumours of hematopoietic and lymphoid tissues.
AB - Natural killer (NK) cell neoplasm is a heterogeneous disease group. In the latest World Health Organization (WHO) classification of tumours of hematopoietic and lymphoid tissues (2008), disease entities considered as NK-cell derivation include NK-lymphoblastic leukemia/lymphoma, chronic lymphoproliferative disorders of NK cells, aggressive NK-cell leukemia, and extranodal NK-cell lymphoma, nasal-type. Despite recent advances in NK-cell research, which have expanded our understanding of the biology of NK-cell neoplasm, it cannot yet be sharply delineated from myeloid neoplasms and T-cell neoplasms even in some "well-known" entity, such as extranodal NK/T-cell lymphoma. This review describes current knowledge of the biology of NK cells and pathology of NK neoplasms as classified in the 2008 WHO classification of tumours of hematopoietic and lymphoid tissues.
KW - Biology
KW - Cell
KW - Lymphoma
KW - NK
KW - Pathology
UR - http://www.scopus.com/inward/record.url?scp=78751585023&partnerID=8YFLogxK
U2 - 10.1007/s12185-010-0738-y
DO - 10.1007/s12185-010-0738-y
M3 - Article
C2 - 21132576
AN - SCOPUS:78751585023
SN - 0925-5710
VL - 92
SP - 681
EP - 689
JO - International journal of hematology
JF - International journal of hematology
IS - 5
ER -