Natural evolution of regurgitation in healthy infants

Badriul Hegar Syarif, Nita R. Dewanti, Muzal Kadim, Fatima Safira Alatas, Agus Firmansyah, Yvan Vandenplas

Research output: Contribution to journalArticlepeer-review

137 Citations (Scopus)


Objectives: To determine the natural history of infant regurgitation during the first year of life. Methods: Parents recorded prospectively the frequency of regurgitation for 1 week before consultation during the first year of life. A sub-group analysis according to the method of feeding was planned. Results: A total of 130 infants of an original sample of 163 (80%) newborns were followed up for 1 year. Daily spilling was highest during the first month of life (73%) and decreased gradually to 50% during the fifth month of life. During the first 2 months of life, 20% of the infants regurgitated more than four times per day. After the age of 12 months, only 4% of the infants had daily regurgitations. Exclusively breastfed infants did regurgitate less than partially breastfed infants. Weight gain was influenced by the frequency of regurgitation, especially in partially breastfed infants. Conclusion: Regurgitation in infancy is common, decreasing from birth, and tends to disappear by 12 months of age. Weight gain during the first 4 months of life is decreased in infants who regurgitate more than four times a day. Our data suggest that exclusively breastfed infants regurgitate less than partially breastfed babies.

Original languageEnglish
Pages (from-to)1189-1193
Number of pages5
JournalActa Paediatrica, International Journal of Paediatrics
Issue number7
Publication statusPublished - Jul 2009


  • Gastro-oesophageal reflux
  • Infants
  • Natural history
  • Regurgitation
  • Spilling
  • Spitting


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