Natural evolution of infantile regurgitation versus the efficacy of thickened formula

Badriul Hegar Syarif, Rastra Rantos, Agus Firmansyah, Jean De Schepper, Yvan Vandenplas

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


Background: Regurgitation is frequent in infants.We evaluated changes in regurgitation among patient groups fed standard formula, standard formula subsequently thickened with cereal, or formula manufactured with bean gum as a thickening agent. Patients and Methods: A prospective, blinded, randomised 1-month intervention trial evaluating the efficacy of parental reassurance of the regurgitating child in combination with 3 formula interventions-standard infant formula (group A); 5 g of rice cereal added to 100mL standard formula (group B); and formula manufactured with bean gum as a thickening agent (group C)-was performed in 60 infants presenting with more than 4 episodes of regurgitation and/or vomiting per day during the week before inclusion. Formula intake, infant comfort, stool aspects, and weight gain were evaluated. All of the infants and data recorded by parents in a diary were evaluated weekly by a blinded health care professional. Results: At baseline, groups A, B, and C were similar for all of the parameters. After the 1-month intervention, regurgitation/ vomiting decreased significantly in all 3 groups (P<0.0005). Although the decrease was largest in group C (-4.2±2.1 episodes/day), the incidence did not differ significantly with groups A or B. At no evaluation interval was there a difference in volume of formula intake, infant comfort, stool frequency, or aspect. After 1 month, weight gain was significantly greater in group C compared with group A (19.9% vs 16.4%; P<0.001). Conclusions: Thickening of formula decreases regurgitation, but not significantly. Parental reassurance remains the cornerstone of the treatment of infant regurgitation.

Original languageEnglish
Pages (from-to)26-30
Number of pages5
JournalJournal of pediatric gastroenterology and nutrition
Issue number1
Publication statusPublished - Jul 2008


  • Antiregurgitation formula
  • Bean gum thickened formula
  • Infant formula
  • Regurgitation
  • Rice cereal thickened formula
  • Vomiting


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