TY - JOUR
T1 - Natural deep eutectic solvents (Nades)
T2 - Phytochemical extraction performance enhancer for pharmaceutical and nutraceutical product development
AU - Hikmawanti, Ni Putu Ermi
AU - Ramadon, Delly
AU - Jantan, Ibrahim
AU - Mun’im, Abdul
N1 - Funding Information:
Funding: This research and APC were funded by Ministry of Research and Technology/National Research and Innovation Agency, Program World Class Research 2021, grant number: NKB‐ 374/UN2.RST/HKP.05.00/2021.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/10
Y1 - 2021/10
N2 - Natural products from plants were extracted and widely studied for their activities against many disease conditions. The selection of the extracting solvent is crucial to develop selective and effective methods for the extraction and isolation of target compounds in the plant matrices. Phar-macological properties of plant extracts and their bioactive principles are related to their excellent solubility, stability, and bioavailability when administered by different routes. This review aims to critically analyze natural deep eutectic solvents (NADES) as green solvents in their application to improve the extraction performance of plant metabolites in terms of their extractability besides the stability, bioactivity, solubility, and bioavailability. Herein, the opportunities for NADES to be used in pharmaceutical formulations development including plant metabolites‐based nutraceuticals are discussed.
AB - Natural products from plants were extracted and widely studied for their activities against many disease conditions. The selection of the extracting solvent is crucial to develop selective and effective methods for the extraction and isolation of target compounds in the plant matrices. Phar-macological properties of plant extracts and their bioactive principles are related to their excellent solubility, stability, and bioavailability when administered by different routes. This review aims to critically analyze natural deep eutectic solvents (NADES) as green solvents in their application to improve the extraction performance of plant metabolites in terms of their extractability besides the stability, bioactivity, solubility, and bioavailability. Herein, the opportunities for NADES to be used in pharmaceutical formulations development including plant metabolites‐based nutraceuticals are discussed.
KW - Bioactivity
KW - Bioavailability
KW - Natural deep eutectic solvents
KW - Pharmaceutical formulation
KW - Solubility
KW - Stability
UR - http://www.scopus.com/inward/record.url?scp=85116211222&partnerID=8YFLogxK
U2 - 10.3390/plants10102091
DO - 10.3390/plants10102091
M3 - Review article
AN - SCOPUS:85116211222
SN - 2223-7747
VL - 10
JO - Plants
JF - Plants
IS - 10
M1 - 2091
ER -