Nasopharyngeal carriage of Streptococcus pneumoniae in adults infected with human immunodeficiency virus in Jakarta, Indonesia

Kuntjoro Harimurti, Siti R.F. Saldi, Esthika Dewiasty, Miftahuddin M. Khoeri, Evy Yunihastuti, Tiara Putri, Wisnu Tafroji, Dodi Safari

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

This study investigated the distribution of serotype and antimicrobial susceptibility of Streptococcus pneumoniae carried by adults infected with human immunodeficiency virus (HIV) in Jakarta, Indonesia. Specimens of nasopharyngeal swab were collected from 200 HIV infected adults aged 21 to 63 years. Identification of S. pneumoniae was done by optochin susceptibility test and PCR for the presence of psaA and lytA genes. Serotyping was performed with sequential multiplex PCR and antibiotic susceptibility with the disk diffusion method. S. pneumoniae strains were carried by 10% adults with serotype 6A/B 20% was common serotype among cultured strains in 20 adults. Most of isolates were susceptible to chloramphenicol (80%) followed by clindamycin (75%), erythromycin (75%), penicillin (55%), and tetracycline (50%). This study found resistance to sulphamethoxazole/trimethoprim was most common with only 15% of strains being susceptible. High non-susceptibility to sulphamethoxazole/trimethoprim was observed in S. pneumoniae strains carried by HIV infected adults in Jakarta, Indonesia.

Original languageEnglish
Pages (from-to)633-638
Number of pages6
JournalJournal of Infection and Public Health
Volume9
Issue number5
DOIs
Publication statusPublished - 1 Sep 2016

Keywords

  • Adults
  • Carriage
  • HIV
  • Jakarta
  • Streptococcus pneumoniae

Fingerprint Dive into the research topics of 'Nasopharyngeal carriage of Streptococcus pneumoniae in adults infected with human immunodeficiency virus in Jakarta, Indonesia'. Together they form a unique fingerprint.

Cite this