Nanoparticle-rich diesel exhaust-induced liver damage via inhibited transactivation of peroxisome proliferator-activated receptor alpha

Yuki Ito, Yukie Yanagiba, Doni Hikmat Ramdhan, Yumi Hayashi, Yufei Li, Akira K. Suzuki, Michihiro Kamijima, Tamie Nakajima

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Diesel exhaust emission contains a high amount of nano-sized particles and is considered to be systemically distributed in the body. However, few studies about the effects of nanoparticle rich-diesel exhaust (NR-DE) on liver have been reported. The present investigation focuses on the effects of NR-DE on livers in rats, especially concerning inflammation and lipid metabolism. Male F344 rats were exposed to fresh air or low (24 ± 7 µg/m3), medium (39 ± 4 µg/m3) and high (138 ± 20 µg/m3) concentrations of NR-DE for 1, 2, or 3 months (5 hours/day, 5 days/week). Exposure to both medium and high concentrations of NR-DE for one month increased plasma asparate aminotransferase and alanine aminotransferase activities, while only high concentrations increased plasma interleukin-6 and hepatic nuclear factor kappa B (NFκB), suggesting that activation of hepatic inflammatory signaling took place. Although these exposures elevated peroxisome proliferator-activated receptor (PPAR) α levels or its binding activity to the response element, neither activated PPARα-target genes such as β-oxidative enzymes nor inhibited NFκB elevation. Thus, NR-DE may contain some materials that inhibit PPARα activation in relation to lipid metabolism and inflammation. Taken together, NR-DE exposure at one month may cause inflammation; however, this finding may not be observed after a longer exposure period.

Original languageEnglish
Pages (from-to)1985-1995
Number of pages11
JournalEnvironmental Toxicology
Volume31
Issue number12
DOIs
Publication statusPublished - 1 Dec 2016

Keywords

  • inflammation
  • lipid metabolism
  • liver
  • nanoparticle-rich diesel exhaust
  • peroxisome proliferator-activated receptor alpha

Fingerprint

Dive into the research topics of 'Nanoparticle-rich diesel exhaust-induced liver damage via inhibited transactivation of peroxisome proliferator-activated receptor alpha'. Together they form a unique fingerprint.

Cite this