Nanocomposites of Terbium Sulfide Nanoparticles with a Chitosan Capping Agent for Antibacterial Applications

This study aims to investigate the effect of alkaline pH on the bottom-up synthesis of nanocomposites (NCs) containing terbium sulfide nanoparticles (Tb₂S₃ NPs), where chitosan (CS) was employed as a capping agent, along with evaluation of the antibacterial activity of these NCs. The NCs were characterized using spectroscopy (FESEM-EDX, Raman, FTIR, XRD, XPS, and DLS), zeta-potential, and TGA. The results of FE-SEM, XPS, Raman, and FTIR characterization support the formation of CS-Tb₂S₃ NPs. A pH variation from 9 to 11 during composite formation was shown to affect the size and composition of NCs. The antibacterial activity of CS-Tb₂S₃ NCs was studied by coating onto commercial contact lenses, where the best loading efficiency of NCs was 48%. The NCs prepared at pH 10 (without contact lenses) had greater antibacterial activity against Staphylococcus aureus, with a zone of inhibition diameter of 7.15 mm. The coating of NCs onto commercial contact lenses was less effective for inhibition of Staphylococcus aureus, in contrast with the greater activity observed for tetracycline. CS-Tb₂S₃ NCs offer promising antimicrobial properties that can be further optimized by control of the surface loading and accessibility of Tb₂S₃ NPs through further study of the role of the chitosan capping agent, since steric effects due to CS are likely to attenuate antimicrobial activity via reduced electron transfer in such nanocomposite systems.