@inproceedings{a00cb17cac9345a2b21eee305f7ded34,
title = "Nano-preparation of Andrographis paniculata extract by casein micelle for antidiabetic agent",
abstract = "Side effects caused by oral medications for person with diabetic are the background of the development of alternative treatments by traditional medicine, herbs. Andrographis paniculata (AP) is one of the herbs that is potent to be anti-diabetic agent. The active compound of AP, andrographolide have been examined to have anti-diabetic activity as α-glucosidase enzyme inhibitor. This research aims to encapsulate sambiloto's extract with casein micelle and produce nanoparticles which have anti-diabetic activity as α-glucosidase inhibitor. Extract of AP is encapsulated by casein micelle and made into nano size using sonicator. The dominant active compounds in AP extract coated by casein are andrographolide, neoandrographolide, 14-deoxy-11,12didehydroandrographolide with encapsulation efficiency of 68.83%, 89.15% and 81.69%, the average diameter of the particles is about 120.57 nm and its loading capacity is 28.85%. AP's extract has antidiabetic activity as α-glucosidase inhibitor with percent inhibition of 95%. The morphology of nanoencapsulated AP's extract analyzed by FE-SEM, were similar with casein micelle.",
keywords = "Andrographispaniculata, andrographolide, antidiabetic, casein, nanoparticles, sambiloto",
author = "Rita Arbianti and Veronica Dewi and Farisa Imansari and Heri Hermansyah and Muhamad Sahlan",
note = "Publisher Copyright: {\textcopyright} 2017 Author(s).; 1st International Symposium of Biomedical Engineering: Biomedical Engineering's Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2016 ; Conference date: 31-05-2016 Through 01-06-2016",
year = "2017",
month = feb,
day = "21",
doi = "10.1063/1.4976779",
language = "English",
series = "AIP Conference Proceedings",
publisher = "American Institute of Physics Inc.",
editor = "Yudan Whulanza and Sugeng Supriadi and Muhamad Sahlan and Basari",
booktitle = "Biomedical Engineering's Recent Progress in Biomaterials, Drugs Development, and Medical Devices",
address = "United States",
}