Nano-preparation of Andrographis paniculata extract by casein micelle for antidiabetic agent

Rita Arbianti, Veronica Dewi, Farisa Imansari, Heri Hermansyah, Muhamad Sahlan

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)

Abstract

Side effects caused by oral medications for person with diabetic are the background of the development of alternative treatments by traditional medicine, herbs. Andrographis paniculata (AP) is one of the herbs that is potent to be anti-diabetic agent. The active compound of AP, andrographolide have been examined to have anti-diabetic activity as α-glucosidase enzyme inhibitor. This research aims to encapsulate sambiloto's extract with casein micelle and produce nanoparticles which have anti-diabetic activity as α-glucosidase inhibitor. Extract of AP is encapsulated by casein micelle and made into nano size using sonicator. The dominant active compounds in AP extract coated by casein are andrographolide, neoandrographolide, 14-deoxy-11,12didehydroandrographolide with encapsulation efficiency of 68.83%, 89.15% and 81.69%, the average diameter of the particles is about 120.57 nm and its loading capacity is 28.85%. AP's extract has antidiabetic activity as α-glucosidase inhibitor with percent inhibition of 95%. The morphology of nanoencapsulated AP's extract analyzed by FE-SEM, were similar with casein micelle.

Original languageEnglish
Title of host publicationBiomedical Engineering's Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publicationProceedings of the 1st International Symposium of Biomedical Engineering, ISBE 2016
EditorsYudan Whulanza, Sugeng Supriadi, Muhamad Sahlan, Basari
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735414853
DOIs
Publication statusPublished - 21 Feb 2017
Event1st International Symposium of Biomedical Engineering: Biomedical Engineering's Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2016 - Depok City, Indonesia
Duration: 31 May 20161 Jun 2016

Publication series

NameAIP Conference Proceedings
Volume1817
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference1st International Symposium of Biomedical Engineering: Biomedical Engineering's Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2016
Country/TerritoryIndonesia
CityDepok City
Period31/05/161/06/16

Keywords

  • Andrographispaniculata
  • andrographolide
  • antidiabetic
  • casein
  • nanoparticles
  • sambiloto

Fingerprint

Dive into the research topics of 'Nano-preparation of Andrographis paniculata extract by casein micelle for antidiabetic agent'. Together they form a unique fingerprint.

Cite this