(+)-N-(2-Hydroxypropyl)lindcarpine: A new cytotoxic aporphine isolated from actinodaphne pruinosa nees

Tiah Rachmatiah, Mat Ropi Mukhtar, Mohd Azlan Nafiah, Muhammad Hanafi, Soleh Kosela, Hiroshi Morita, Marc Litaudon, Khalijah Awang, Hanita Omar, A. Hamid, A. Hadi

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Abstract

One new alkaloid; (+)-N-(2-hydroxypropyl)lindcarpine (1), together with four known aporphine alkaloids, (+)-boldine (2) (+)-norboldine (3), (+)-lindcarpine (4) and (+)-methyllindcarpine (5) were isolated from the stem bark of Actinodaphne pruinosa Nees (Lauraceae). (+)-N-(2-Hydroxypropyl) lindcarpine (1) exhibited cytotoxic activity against P-388 murine leukemia cells with an IC50 value of 3.9 μg/mL. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D- NMR, IR, UV, and HRESIMS.

Original languageEnglish
Pages (from-to)2850-2856
Number of pages7
JournalMolecules
Volume14
Issue number8
DOIs
Publication statusPublished - 1 Aug 2009

Keywords

  • Actinodaphne pruinosa
  • Aporphine alkaloid
  • Cytotoxic
  • Lauraceae

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    Rachmatiah, T., Mukhtar, M. R., Nafiah, M. A., Hanafi, M., Kosela, S., Morita, H., Litaudon, M., Awang, K., Omar, H., Hamid, A., & Hadi, A. (2009). (+)-N-(2-Hydroxypropyl)lindcarpine: A new cytotoxic aporphine isolated from actinodaphne pruinosa nees. Molecules, 14(8), 2850-2856. https://doi.org/10.3390/molecules14082850