(+)-N-(2-Hydroxypropyl)lindcarpine: A new cytotoxic aporphine isolated from actinodaphne pruinosa nees

Tiah Rachmatiah; Mat Ropi Mukhtar; Mohd Azlan Nafiah; Muhammad Hanafi; Soleh Kosela; Hiroshi Morita; Marc Litaudon; Khalijah Awang; Hanita Omar; A. Hamid; A. Hadi

doi:10.3390/molecules14082850

(+)-N-(2-Hydroxypropyl)lindcarpine: A new cytotoxic aporphine isolated from actinodaphne pruinosa nees

Tiah Rachmatiah, Mat Ropi Mukhtar, Mohd Azlan Nafiah, Muhammad Hanafi, Soleh Kosela, Hiroshi Morita, Marc Litaudon, Khalijah Awang, Hanita Omar, A. Hamid, A. Hadi

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

One new alkaloid; (+)-N-(2-hydroxypropyl)lindcarpine (1), together with four known aporphine alkaloids, (+)-boldine (2) (+)-norboldine (3), (+)-lindcarpine (4) and (+)-methyllindcarpine (5) were isolated from the stem bark of Actinodaphne pruinosa Nees (Lauraceae). (+)-N-(2-Hydroxypropyl) lindcarpine (1) exhibited cytotoxic activity against P-388 murine leukemia cells with an IC⁵⁰ value of 3.9 μg/mL. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D- NMR, IR, UV, and HRESIMS.

Original language	English
Pages (from-to)	2850-2856
Number of pages	7
Journal	Molecules
Volume	14
Issue number	8
DOIs	https://doi.org/10.3390/molecules14082850
Publication status	Published - Aug 2009

Keywords

Actinodaphne pruinosa
Aporphine alkaloid
Cytotoxic
Lauraceae

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10.3390/molecules14082850

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title = "(+)-N-(2-Hydroxypropyl)lindcarpine: A new cytotoxic aporphine isolated from actinodaphne pruinosa nees",

abstract = "One new alkaloid; (+)-N-(2-hydroxypropyl)lindcarpine (1), together with four known aporphine alkaloids, (+)-boldine (2) (+)-norboldine (3), (+)-lindcarpine (4) and (+)-methyllindcarpine (5) were isolated from the stem bark of Actinodaphne pruinosa Nees (Lauraceae). (+)-N-(2-Hydroxypropyl) lindcarpine (1) exhibited cytotoxic activity against P-388 murine leukemia cells with an IC50 value of 3.9 μg/mL. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D- NMR, IR, UV, and HRESIMS.",

keywords = "Actinodaphne pruinosa, Aporphine alkaloid, Cytotoxic, Lauraceae",

author = "Tiah Rachmatiah and Mukhtar, {Mat Ropi} and Nafiah, {Mohd Azlan} and Muhammad Hanafi and Soleh Kosela and Hiroshi Morita and Marc Litaudon and Khalijah Awang and Hanita Omar and A. Hamid and A. Hadi",

year = "2009",

month = aug,

doi = "10.3390/molecules14082850",

language = "English",

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pages = "2850--2856",

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T1 - (+)-N-(2-Hydroxypropyl)lindcarpine

T2 - A new cytotoxic aporphine isolated from actinodaphne pruinosa nees

AU - Rachmatiah, Tiah

AU - Mukhtar, Mat Ropi

AU - Nafiah, Mohd Azlan

AU - Hanafi, Muhammad

AU - Kosela, Soleh

AU - Morita, Hiroshi

AU - Litaudon, Marc

AU - Awang, Khalijah

AU - Omar, Hanita

AU - Hamid, A.

AU - Hadi, A.

PY - 2009/8

Y1 - 2009/8

N2 - One new alkaloid; (+)-N-(2-hydroxypropyl)lindcarpine (1), together with four known aporphine alkaloids, (+)-boldine (2) (+)-norboldine (3), (+)-lindcarpine (4) and (+)-methyllindcarpine (5) were isolated from the stem bark of Actinodaphne pruinosa Nees (Lauraceae). (+)-N-(2-Hydroxypropyl) lindcarpine (1) exhibited cytotoxic activity against P-388 murine leukemia cells with an IC50 value of 3.9 μg/mL. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D- NMR, IR, UV, and HRESIMS.

AB - One new alkaloid; (+)-N-(2-hydroxypropyl)lindcarpine (1), together with four known aporphine alkaloids, (+)-boldine (2) (+)-norboldine (3), (+)-lindcarpine (4) and (+)-methyllindcarpine (5) were isolated from the stem bark of Actinodaphne pruinosa Nees (Lauraceae). (+)-N-(2-Hydroxypropyl) lindcarpine (1) exhibited cytotoxic activity against P-388 murine leukemia cells with an IC50 value of 3.9 μg/mL. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D- NMR, IR, UV, and HRESIMS.

KW - Actinodaphne pruinosa

KW - Aporphine alkaloid

KW - Cytotoxic

KW - Lauraceae

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U2 - 10.3390/molecules14082850

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AN - SCOPUS:69549114251

SN - 1420-3049

VL - 14

SP - 2850

EP - 2856

JO - Molecules

JF - Molecules

IS - 8

ER -

(+)-N-(2-Hydroxypropyl)lindcarpine: A new cytotoxic aporphine isolated from actinodaphne pruinosa nees

Abstract

Keywords

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