TY - JOUR
T1 - Mycophenolate mofetil versus cyclophosphamide for therapy of lupus nephritis
T2 - An evidence-based case report from systematic reviews and meta-analyses
AU - Pramono, Laurentius A.
AU - Karim, Birry
AU - Rajabto, Wulyo
AU - Siregar, Parlindungan
AU - Sukmana, Nanang
AU - Setyohadi, Bambang
N1 - Publisher Copyright:
© 2012 Faculty of Medicine, Universitas Indonesia. All rights reserved.
PY - 2012/2
Y1 - 2012/2
N2 - Background: The aim of this case study is to compare the effectiveness between cyclophosphamide and mycophenolate mofetil to achieve remission of lupus nephritis in an evidence-based case report from meta-analyses. Methods: Method in this case study is evidence-based case report using meta-analyses. Clinical question used in this paper is; which immunosuppressant gives better result in achieving remission in lupus nephritis patient: cyclophosphamide or mycophenolate mofetil? To answer this question, we search the evidence from PubMed with the keywords: “lupus nephritis AND mycophenolate mofetil AND cyclophosphamide” with inclusion criteria of meta-analysis, written in English, and focused comparing cyclophosphamide and mycophenolate mofetil. Results: From the searching method, we found 11 articles which is relevant. One has been excluded since it written in Hebrew, 4 articles excluded since are not focus answering the clinical question. At the end, 6 studies were included to the critical appraisal step. Conclusion: Based on the evidences, mycophenolate mofetil is non-inferior to cyclophosphamide in achieving remission in lupus nephritis patients, but with the better safety profile. Patient in our case study get mycophenolate mofetil and shows better clinical condition towards remission as she are evaluated in the outpatient clinic.
AB - Background: The aim of this case study is to compare the effectiveness between cyclophosphamide and mycophenolate mofetil to achieve remission of lupus nephritis in an evidence-based case report from meta-analyses. Methods: Method in this case study is evidence-based case report using meta-analyses. Clinical question used in this paper is; which immunosuppressant gives better result in achieving remission in lupus nephritis patient: cyclophosphamide or mycophenolate mofetil? To answer this question, we search the evidence from PubMed with the keywords: “lupus nephritis AND mycophenolate mofetil AND cyclophosphamide” with inclusion criteria of meta-analysis, written in English, and focused comparing cyclophosphamide and mycophenolate mofetil. Results: From the searching method, we found 11 articles which is relevant. One has been excluded since it written in Hebrew, 4 articles excluded since are not focus answering the clinical question. At the end, 6 studies were included to the critical appraisal step. Conclusion: Based on the evidences, mycophenolate mofetil is non-inferior to cyclophosphamide in achieving remission in lupus nephritis patients, but with the better safety profile. Patient in our case study get mycophenolate mofetil and shows better clinical condition towards remission as she are evaluated in the outpatient clinic.
KW - Cyclophosphamide
KW - Evidence-based case report
KW - Lupus nephritis
KW - Meta-analysis
KW - Mycophenolate mofetil
KW - Remission
KW - Systematic review
UR - http://www.scopus.com/inward/record.url?scp=85008895103&partnerID=8YFLogxK
U2 - 10.13181/mji.v21i1.474
DO - 10.13181/mji.v21i1.474
M3 - Article
AN - SCOPUS:85008895103
SN - 0853-1773
VL - 21
SP - 44
EP - 51
JO - Medical Journal of Indonesia
JF - Medical Journal of Indonesia
IS - 1
ER -