Multiple Organ Disfunction Syndrome: Patophysiology and Diagnosis

Velma Hermanto, Zulkifli Amin

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The term Multiple Organ Dysfunction Syndrome (MODS) describes the presence of altered organ function in an acutely ill patient (involves >2 systems), such that homeostasis cannot be maintained without intervention. Infection is the most important clinical correlate of the syndrome. Other etiology comprises of trauma and non-infectious inflammation process. Some hypotheses - such as the mediator hypothesis, gut-as motor hypothesis, microvascular failure hypothesis, two-hit hypothesis, and integrated hypothesis - were assumed to have roles in MODS pathogenesis. Generally, potential pathophysiologic mechanisms involved in that MODS hypotheses were primary cellular injury, inadequate tissue/ organ perfusion, diffuse endothelial injury, circulating humoral factors and inflammatory mediators, protein calorie malnutrition, bacterialtoxin translocation, defective red blood cells, and also adverse effect of directed treatment. Evaluation of MODS principally includes the dysfunction of respiratory, cardiovascular, kidney, liver, hematology, and central nervous systems. Prevention was the most important step since there is yet any specific therapy targetted at MODS. The management was mainly supportive.
Original languageEnglish
JournalJournal of the Indonesian Medical Association
Issue number11
Publication statusPublished - 2009


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