Multimodal Deep Boltzmann Machines for feature selection on gene expression data

Arida Ferti Syafiandini, Ito Wasito, Setiadi Yazid, Aries Fitriawan, Mukhlis Amien

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

6 Citations (Scopus)

Abstract

In this paper, multimodal Deep Boltzmann Machines (DBM) is employed to learn important genes (biomarkers) on gene expression data from human carcinoma colorectal. The learning process involves gene expression data and several patient phenotypes such as lymph node and distant metastasis occurrence. The proposed framework in this paper uses multimodal DBM to train records with metastasis occurrence. Later, the trained model is tested using records with no metastasis occurrence. After that, Mean Squared Error (MSE) is measured from the reconstructed and the original gene expression data. Genes are ranked based on the MSE value. The first gene has the highest MSE value. After that, k-means clustering is performed using various number of genes. Features that give the highest purity index are considered as the important genes. The important genes obtained from the proposed framework and two sample t-test are being compared. From the accuracy of metastasis classification, the proposed framework gives higher results compared to the top genes from two sample t-test.

Original languageEnglish
Title of host publication2016 International Conference on Advanced Computer Science and Information Systems, ICACSIS 2016
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages407-412
Number of pages6
ISBN (Electronic)9781509046294
DOIs
Publication statusPublished - 6 Mar 2017
Event8th International Conference on Advanced Computer Science and Information Systems, ICACSIS 2016 - Malang, Indonesia
Duration: 15 Oct 201616 Oct 2016

Publication series

Name2016 International Conference on Advanced Computer Science and Information Systems, ICACSIS 2016

Conference

Conference8th International Conference on Advanced Computer Science and Information Systems, ICACSIS 2016
Country/TerritoryIndonesia
CityMalang
Period15/10/1616/10/16

Keywords

  • gene expression
  • microarray
  • multimodal DBM

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