Multifunctional microsphere formulation of fluorescent magnetic properties for drug delivery system

Eny Kusrini, Riesna Prassanti, Dwi Marta, Cindy Gunawan

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)

Abstract

The microsphere formulations of Chit/TPP/Sm/Fe3O4/Rn were prepared by an ionic gelation technique, where Chit=chitosan, TPP=tripolyphosphate, Sm=samarium and Rn=ranitidine. Optimum of microsphere formulation exhibit magnetic and fluorescent properties with adsorption efficiency of ∼92% was obtained for Chit/TPP/Sm/Fe3O4/Rn with ratio 400:500:50:1:20. Fluorescence intensity of microsphere formulations increased with the cumulative amount release of ranitidine, so that the changing of fluorescence intensity at wavelength of 590 nm referring to the Sm3+ ion could be used as indicator in DDS. With the demonstration of sustained release from microsphere formulation, it allows to investigate the applications to other drugs.

Original languageEnglish
Title of host publicationBiomedical Engineering's Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publicationProceedings of the 1st International Symposium of Biomedical Engineering, ISBE 2016
EditorsYudan Whulanza, Sugeng Supriadi, Muhamad Sahlan, Basari
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735414853
DOIs
Publication statusPublished - 21 Feb 2017
Event1st International Symposium of Biomedical Engineering: Biomedical Engineering's Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2016 - Depok City, Indonesia
Duration: 31 May 20161 Jun 2016

Publication series

NameAIP Conference Proceedings
Volume1817
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference1st International Symposium of Biomedical Engineering: Biomedical Engineering's Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2016
Country/TerritoryIndonesia
CityDepok City
Period31/05/161/06/16

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