Multifocal recurrence of medulloblastoma: A long follow-up case study

Benny Zulkarnaien, Edwin Suharlim, Eka Susanto, Soehartati Argadikoesoema Gondhowiardjo

Research output: Contribution to journalArticlepeer-review

Abstract

Medulloblastoma is the most common malignant brain tumor in pediatric patients. Leptomeningeal dissemination often occurs in the spinal canal and rarely into the supratentorial as an extra-axial lesion. This study followed an 8-year progression of multifocal medulloblastoma recurrence as supratentorial metastasis that mimics an intra-axial mass of the temporal lobe. Pathologic examination of the temporal mass showed densely packed small round blue cells that are distributed in a ribboning pattern with areas of necrosis, rosette formation, and mitosis. Ki-67 immunohistochemical staining of the tumor showed a high proliferation index of 40% and revealed positive results for synaptophysin and negative results for glial fibrillary acidic protein and Β-catenin. A long follow-up is essential to diagnose the recurrence and elucidate the progression of medulloblastoma.

Original languageEnglish
Pages (from-to)93-99
Number of pages7
JournalMedical Journal of Indonesia
Volume29
Issue number1
DOIs
Publication statusPublished - Mar 2020

Keywords

  • Intra-axial mass
  • Long follow-up
  • Medulloblastoma
  • Recurrence

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