Multidrug Resistance and Extensively Drug-Resistance in Staphylococcus aureus, Staphylococcus epidermidis, and Staphylococcus haemolyticus

Antimicrobial resistance in bacteria has become a leading global public health issue. has Staphylococcus sp.an efficient mechanism to deal with antimicrobial agents that make them hard to treat in hospital-acquired andcommunity-acquired infections. This study was conducted due to limited data about multidrug resistance andextensively drug resistance in . in Indonesia. This study wa Staphylococcus sp s a descriptive retrospective studyusing a cross-sectional design to get the prevalence and antimicrobial susceptibility of , S. haemolyticus S. aureus,and The data w secondary data extracted from WHONET 2022 soft S. epidermidis. ere ware. This study's data werefrom bacteria from samples sent to UKK LMK FKUI, Jakarta from 2017 to 2021 for routine diagnostic. In thisstudy, we found that the prevalence of methicillin-resistant was 24.9%, methicillin-resistant S. aureus S.epidermidis S. haemolyticus S. aureus was 65,5%, and methicillin-resistant was 86.8%. The prevalence of MDR isless than and respectively. MDR consistently above 85% S. epidermidis S. haemolyticus, S. haemolyticus waseach year, while was above 50% and was below 50%. XDR Staphylo S. epidermidis S. aureus coccus was onlyfound in and , i.e. three and seven XDR isolates of S. aureus S. haemolyticus S. aureus and S. haemolyticusrespectively during 2017-2021. Although we could not find any pan-resistant isolates from all samples, we foundmethicillin-resistant and isolates that were also resista S. aureus S. haemolyticus nt to vancomycin and linezolid. S.haemolyticus S. epidermidis coagulase-negative Staphylo dan were an important species that can't be coccusneglected due to the high percentage of MDR and the discoveries of XDR in so that they have the S. haemolyticuspotential to disseminate resistance plasmids to the more virulent bacteria. Therefore we need to control the use ofantimicrobial agent to prevent this resistance.