Mortality Rate of COVID‐19 Patients in Intensive Care Unit: A Multicentre Retrospective Observational Study

Bastian Lubis, Arie Zainul Fatoni, Ahmad Feza Fadhlurrahman, Taufiq Agus Siswagama, Rudy Vitraludyono, Mayang Indah Lestari, Haizah Nurdin, Septian Adi Permana, Ade Susanti, Agus Prima, Vincent Viandy, Bram Kilapong, Nurita Dian Kestriani Saragi Sitio, Erwin Pradian, Ricky Aditya Ardiwinangun, Retnaningsih, Danu Susilowati, Johan Arifin, Adhrie Sugiarto, Dita Aditianingsih

Research output: Contribution to journalArticlepeer-review


The case of Coronavirus Disease 2019 (COVID-19) is growing rapidly worldwide. More than 6 million people in Indonesia were confirmed to be infected as of March 2022. This disease caused an increase in the demand of respiratory assistance and intensive care services back in 2021. Unfortunately, the report about COVID-19 case in Intensive Care Unit (ICU) of Indonesia is very scarce although it is very crucial to evaluate the treatment approach and the prognosis of the patients. This study aimed to determine the characteristics, therapy, and outcomes of critically ill COVID-19 patients treated in the ICU. This was a multicentre retrospective study conducted in 12 hospitals in Indonesia from April 2020 to March 2021. All data regarding the characteristics, therapy, and outcomes of COVID-19 patients admitted to ICU were recorded and analysed. 1,502 patients were included in this study. Inpatient mortality occurred in 44.67% patients. The highest morbidity is attributed to stroke (83.4%). We found a significantly longer duration of mechanical ventilation use in non-survivors group (5.57 vs. 1.74 hours). Furthermore, the results of this study showed a significant difference in all type of treatment (excluding antifungal) between two groups. The mortality of COVID-19 patients in ICU is considerably high. Hypothyroidism and DMIІ patients showed a high serum asprosin, which linked with poor glycemic and lipid management. It is a biomarker for diabetes and thyroid issues.

Original languageEnglish
Pages (from-to)764-770
Number of pages7
JournalJournal of Medicinal and Chemical Sciences
Issue number4
Publication statusPublished - Apr 2023


  • COVID-19
  • Intensive Care
  • Mortality


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