TY - JOUR
T1 - Mortality Rate of COVID‐19 Patients in Intensive Care Unit
T2 - A Multicentre Retrospective Observational Study
AU - Lubis, Bastian
AU - Fatoni, Arie Zainul
AU - Fadhlurrahman, Ahmad Feza
AU - Siswagama, Taufiq Agus
AU - Vitraludyono, Rudy
AU - Lestari, Mayang Indah
AU - Nurdin, Haizah
AU - Permana, Septian Adi
AU - Susanti, Ade
AU - Prima, Agus
AU - Viandy, Vincent
AU - Kilapong, Bram
AU - Saragi Sitio, Nurita Dian Kestriani
AU - Pradian, Erwin
AU - Ardiwinangun, Ricky Aditya
AU - Retnaningsih,
AU - Susilowati, Danu
AU - Arifin, Johan
AU - Sugiarto, Adhrie
AU - Aditianingsih, Dita
N1 - Funding Information:
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Publisher Copyright:
© 2023 by SPC (Sami Publishing Company)
PY - 2023/4
Y1 - 2023/4
N2 - The case of Coronavirus Disease 2019 (COVID-19) is growing rapidly worldwide. More than 6 million people in Indonesia were confirmed to be infected as of March 2022. This disease caused an increase in the demand of respiratory assistance and intensive care services back in 2021. Unfortunately, the report about COVID-19 case in Intensive Care Unit (ICU) of Indonesia is very scarce although it is very crucial to evaluate the treatment approach and the prognosis of the patients. This study aimed to determine the characteristics, therapy, and outcomes of critically ill COVID-19 patients treated in the ICU. This was a multicentre retrospective study conducted in 12 hospitals in Indonesia from April 2020 to March 2021. All data regarding the characteristics, therapy, and outcomes of COVID-19 patients admitted to ICU were recorded and analysed. 1,502 patients were included in this study. Inpatient mortality occurred in 44.67% patients. The highest morbidity is attributed to stroke (83.4%). We found a significantly longer duration of mechanical ventilation use in non-survivors group (5.57 vs. 1.74 hours). Furthermore, the results of this study showed a significant difference in all type of treatment (excluding antifungal) between two groups. The mortality of COVID-19 patients in ICU is considerably high. Hypothyroidism and DMIІ patients showed a high serum asprosin, which linked with poor glycemic and lipid management. It is a biomarker for diabetes and thyroid issues.
AB - The case of Coronavirus Disease 2019 (COVID-19) is growing rapidly worldwide. More than 6 million people in Indonesia were confirmed to be infected as of March 2022. This disease caused an increase in the demand of respiratory assistance and intensive care services back in 2021. Unfortunately, the report about COVID-19 case in Intensive Care Unit (ICU) of Indonesia is very scarce although it is very crucial to evaluate the treatment approach and the prognosis of the patients. This study aimed to determine the characteristics, therapy, and outcomes of critically ill COVID-19 patients treated in the ICU. This was a multicentre retrospective study conducted in 12 hospitals in Indonesia from April 2020 to March 2021. All data regarding the characteristics, therapy, and outcomes of COVID-19 patients admitted to ICU were recorded and analysed. 1,502 patients were included in this study. Inpatient mortality occurred in 44.67% patients. The highest morbidity is attributed to stroke (83.4%). We found a significantly longer duration of mechanical ventilation use in non-survivors group (5.57 vs. 1.74 hours). Furthermore, the results of this study showed a significant difference in all type of treatment (excluding antifungal) between two groups. The mortality of COVID-19 patients in ICU is considerably high. Hypothyroidism and DMIІ patients showed a high serum asprosin, which linked with poor glycemic and lipid management. It is a biomarker for diabetes and thyroid issues.
KW - COVID-19
KW - Intensive Care
KW - Mortality
UR - http://www.scopus.com/inward/record.url?scp=85141998199&partnerID=8YFLogxK
U2 - 10.26655/JMCHEMSCI.2023.4.7
DO - 10.26655/JMCHEMSCI.2023.4.7
M3 - Article
AN - SCOPUS:85141998199
SN - 2651-4702
VL - 6
SP - 764
EP - 770
JO - Journal of Medicinal and Chemical Sciences
JF - Journal of Medicinal and Chemical Sciences
IS - 4
ER -
