TY - JOUR
T1 - Morphological analysis of Goniopora species coral powder and composite scaffold using micro-computed tomography
AU - Julia, Vera
AU - Latief, Fourier Dzar Eljabbar
AU - Mauludin, Rachmat
AU - Kartasasmita, Rahmana Emran
AU - Latief, Benny Sjariefsjah
N1 - Funding Information:
The author gratefully acknowledge Basril Abbas, from National Nuclear Energy Agency of Indonesia (BATAN) to assist the preparation of Coral Goniopora powder particle.
Publisher Copyright:
© 2019 Journal of International Dental and Medical Research.
PY - 2019
Y1 - 2019
N2 - Coral is considered useful for scaffold formation because of its osteoconductivity, biocompatibility, and good resorption properties. To further facilitate the optimal clinical application in oral surgery, Goniopora species coral powder has been formulated into an appropriate semi solid composite scaffold to fulfill pharmaceutical safety, efficacy, and quality requirements. The aim of this study was to analyze the morphological structure of goniopora coral powder and its composite scaffolds. Composite bone graft was formulated by mixing Goniopora sp. coral powder with a sterile semisolid base made of excipient mixture (polyvinylpyrrolidone and poloxamer 188, 1:1). The prepared coral raw material, coral powder, and its composite scaffold were observed under a scanning electron microscope (SEM), and the morphological structures of Goniopora sp. coral powder and its composite scaffold were analyzed by micro-computed tomography (μ-CT). SEM observations of Goniopora sp. raw material, coral powder particles, and its composite scaffold revealed a good mineral phase distribution network. The histogram of the gray scale index of μ-CT scan revealed the sample's composition in terms of its components' pseudo-density. The mixture of the coral powder and the sterile semisolid base increased the resultant powder particle density and formed a composite coral scaffold, suggesting the suitability of the excipient mixture as an adhesive agent.
AB - Coral is considered useful for scaffold formation because of its osteoconductivity, biocompatibility, and good resorption properties. To further facilitate the optimal clinical application in oral surgery, Goniopora species coral powder has been formulated into an appropriate semi solid composite scaffold to fulfill pharmaceutical safety, efficacy, and quality requirements. The aim of this study was to analyze the morphological structure of goniopora coral powder and its composite scaffolds. Composite bone graft was formulated by mixing Goniopora sp. coral powder with a sterile semisolid base made of excipient mixture (polyvinylpyrrolidone and poloxamer 188, 1:1). The prepared coral raw material, coral powder, and its composite scaffold were observed under a scanning electron microscope (SEM), and the morphological structures of Goniopora sp. coral powder and its composite scaffold were analyzed by micro-computed tomography (μ-CT). SEM observations of Goniopora sp. raw material, coral powder particles, and its composite scaffold revealed a good mineral phase distribution network. The histogram of the gray scale index of μ-CT scan revealed the sample's composition in terms of its components' pseudo-density. The mixture of the coral powder and the sterile semisolid base increased the resultant powder particle density and formed a composite coral scaffold, suggesting the suitability of the excipient mixture as an adhesive agent.
KW - Electron microscope tomography
KW - Micro-computed tomography
KW - Tissue scaffold
UR - http://www.scopus.com/inward/record.url?scp=85069495746&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85069495746
SN - 1309-100X
VL - 12
SP - 465
EP - 471
JO - Journal of International Dental and Medical Research
JF - Journal of International Dental and Medical Research
IS - 2
ER -