Morphological analysis of Goniopora species coral powder and composite scaffold using micro-computed tomography

Vera Julia, Fourier Dzar Eljabbar Latief, Rachmat Mauludin, Rahmana Emran Kartasasmita, Benny Sjariefsjah Latief

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Coral is considered useful for scaffold formation because of its osteoconductivity, biocompatibility, and good resorption properties. To further facilitate the optimal clinical application in oral surgery, Goniopora species coral powder has been formulated into an appropriate semi solid composite scaffold to fulfill pharmaceutical safety, efficacy, and quality requirements. The aim of this study was to analyze the morphological structure of goniopora coral powder and its composite scaffolds. Composite bone graft was formulated by mixing Goniopora sp. coral powder with a sterile semisolid base made of excipient mixture (polyvinylpyrrolidone and poloxamer 188, 1:1). The prepared coral raw material, coral powder, and its composite scaffold were observed under a scanning electron microscope (SEM), and the morphological structures of Goniopora sp. coral powder and its composite scaffold were analyzed by micro-computed tomography (μ-CT). SEM observations of Goniopora sp. raw material, coral powder particles, and its composite scaffold revealed a good mineral phase distribution network. The histogram of the gray scale index of μ-CT scan revealed the sample's composition in terms of its components' pseudo-density. The mixture of the coral powder and the sterile semisolid base increased the resultant powder particle density and formed a composite coral scaffold, suggesting the suitability of the excipient mixture as an adhesive agent.

Original languageEnglish
Pages (from-to)465-471
Number of pages7
JournalJournal of International Dental and Medical Research
Volume12
Issue number2
Publication statusPublished - 2019

Keywords

  • Electron microscope tomography
  • Micro-computed tomography
  • Tissue scaffold

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