Infiltration of macrophages in the glomeruli or tubulointerstitium play an important role in the pathogenesis of various types of renal disease. The mechanisms responsible for the migration of monocytes from the intravascular compartment to the place of tissue injury are now increasingly understood. Monocyte chemoattractant protein-1 (MCP-1) is one of chemotactic cytokines involved in the migration of monocytes. This paper reviewed our studies and others on the role of MCP-1 in the migration of monocytes into the glomeruli and tubulointerstitium, in glomerular diseases and acute renal allograft rejection.
- Renal allograft rejection