Molecular understanding of curcumin in diabetic nephropathy

Vivian, Kenji Suzuki, Punniyakoti T. Veeraveedu, Somasundaram Arumugam, Arun P. Lakshmanan, Hirohito Sone, Kenichi Watanabe

Research output: Contribution to journalReview articlepeer-review

34 Citations (Scopus)

Abstract

Diabetic nephropathy is characterized by a plethora of signaling abnormalities. Recent trials have suggested that intensive glucose-lowering treatment leads to hypoglycemic events, which can be dangerous. Curcumin is the active ingredient of turmeric, which has been widely used in many countries for centuries to treat numerous diseases. The preventive and therapeutic properties of curcumin are associated with its antioxidant and anti-inflammatory properties. Here, we highlight the renoprotective role of curcumin in diabetes mellitus (DM) with an emphasis on the molecular basis of this effect. We also briefly discuss the numerous approaches that have been undertaken to improve the pharmacokinetics of curcumin.

Original languageEnglish
Pages (from-to)756-763
Number of pages8
JournalDrug Discovery Today
Volume18
Issue number15-16
DOIs
Publication statusPublished - 1 Aug 2013

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