TY - JOUR
T1 - Molecular understanding of curcumin in diabetic nephropathy
AU - Vivian, null
AU - Suzuki, Kenji
AU - Veeraveedu, Punniyakoti T.
AU - Arumugam, Somasundaram
AU - Lakshmanan, Arun P.
AU - Sone, Hirohito
AU - Watanabe, Kenichi
PY - 2013/8
Y1 - 2013/8
N2 - Diabetic nephropathy is characterized by a plethora of signaling abnormalities. Recent trials have suggested that intensive glucose-lowering treatment leads to hypoglycemic events, which can be dangerous. Curcumin is the active ingredient of turmeric, which has been widely used in many countries for centuries to treat numerous diseases. The preventive and therapeutic properties of curcumin are associated with its antioxidant and anti-inflammatory properties. Here, we highlight the renoprotective role of curcumin in diabetes mellitus (DM) with an emphasis on the molecular basis of this effect. We also briefly discuss the numerous approaches that have been undertaken to improve the pharmacokinetics of curcumin.
AB - Diabetic nephropathy is characterized by a plethora of signaling abnormalities. Recent trials have suggested that intensive glucose-lowering treatment leads to hypoglycemic events, which can be dangerous. Curcumin is the active ingredient of turmeric, which has been widely used in many countries for centuries to treat numerous diseases. The preventive and therapeutic properties of curcumin are associated with its antioxidant and anti-inflammatory properties. Here, we highlight the renoprotective role of curcumin in diabetes mellitus (DM) with an emphasis on the molecular basis of this effect. We also briefly discuss the numerous approaches that have been undertaken to improve the pharmacokinetics of curcumin.
UR - http://www.scopus.com/inward/record.url?scp=84881183241&partnerID=8YFLogxK
U2 - 10.1016/j.drudis.2013.04.009
DO - 10.1016/j.drudis.2013.04.009
M3 - Review article
C2 - 23651956
AN - SCOPUS:84881183241
SN - 1359-6446
VL - 18
SP - 756
EP - 763
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 15-16
ER -