Molecular pathological changes induced by ultraviolet light during the development of skin cancer

Masato Ueda, Mpu Kanoko, Santoso Comain, Mochtar Hamzah, Evert Poetiray, Joedo Prihartono, Yoshiyuki Ohno, Masamitsu Ichihashi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Ultraviolet light (UV) is the most important cause of human skin cancers. UV results in carcinogenesis through direct effects on the target cell and indirect effects on the host (immunosuppression). Recent studies have begun to uncover the molecular mechanisms involved. Here, we discuss recent findings and developments in the molecular biology of UV-carcinogenesis in the skin, by focusing on DNA damage and DNA repair, the p53 tumor suppressor gene, apoptosis, the patched gene and telomerase activity.

Original languageEnglish
Pages (from-to)118-132
Number of pages15
JournalMedical Journal of Indonesia
Volume9
Issue number2
DOIs
Publication statusPublished - 1 Apr 2000

Keywords

  • Carcinogenesis
  • DNA repair
  • Ltraviolet light
  • P53
  • Patched gene
  • Skin cancer
  • Telomerase

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