Molecular pathological changes induced by ultraviolet light during the development of skin cancer

Masato Ueda; Mpu Kanoko; Santoso Comain; Mochtar Hamzah; Evert Poetiray; Joedo Prihartono; Yoshiyuki Ohno; Masamitsu Ichihashi

doi:10.13181/mji.v9i2.664

Molecular pathological changes induced by ultraviolet light during the development of skin cancer

Masato Ueda, Mpu Kanoko, Santoso Comain, Mochtar Hamzah, Evert Poetiray, Joedo Prihartono, Yoshiyuki Ohno, Masamitsu Ichihashi

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Ultraviolet light (UV) is the most important cause of human skin cancers. UV results in carcinogenesis through direct effects on the target cell and indirect effects on the host (immunosuppression). Recent studies have begun to uncover the molecular mechanisms involved. Here, we discuss recent findings and developments in the molecular biology of UV-carcinogenesis in the skin, by focusing on DNA damage and DNA repair, the p53 tumor suppressor gene, apoptosis, the patched gene and telomerase activity.

Original language	English
Pages (from-to)	118-132
Number of pages	15
Journal	Medical Journal of Indonesia
Volume	9
Issue number	2
DOIs	https://doi.org/10.13181/mji.v9i2.664
Publication status	Published - 1 Apr 2000

Keywords

Carcinogenesis
DNA repair
Ltraviolet light
P53
Patched gene
Skin cancer
Telomerase

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10.13181/mji.v9i2.664

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title = "Molecular pathological changes induced by ultraviolet light during the development of skin cancer",

abstract = "Ultraviolet light (UV) is the most important cause of human skin cancers. UV results in carcinogenesis through direct effects on the target cell and indirect effects on the host (immunosuppression). Recent studies have begun to uncover the molecular mechanisms involved. Here, we discuss recent findings and developments in the molecular biology of UV-carcinogenesis in the skin, by focusing on DNA damage and DNA repair, the p53 tumor suppressor gene, apoptosis, the patched gene and telomerase activity.",

keywords = "Carcinogenesis, DNA repair, Ltraviolet light, P53, Patched gene, Skin cancer, Telomerase",

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T1 - Molecular pathological changes induced by ultraviolet light during the development of skin cancer

AU - Ueda, Masato

AU - Kanoko, Mpu

AU - Comain, Santoso

AU - Hamzah, Mochtar

AU - Poetiray, Evert

AU - Prihartono, Joedo

AU - Ohno, Yoshiyuki

AU - Ichihashi, Masamitsu

PY - 2000/4/1

Y1 - 2000/4/1

N2 - Ultraviolet light (UV) is the most important cause of human skin cancers. UV results in carcinogenesis through direct effects on the target cell and indirect effects on the host (immunosuppression). Recent studies have begun to uncover the molecular mechanisms involved. Here, we discuss recent findings and developments in the molecular biology of UV-carcinogenesis in the skin, by focusing on DNA damage and DNA repair, the p53 tumor suppressor gene, apoptosis, the patched gene and telomerase activity.

AB - Ultraviolet light (UV) is the most important cause of human skin cancers. UV results in carcinogenesis through direct effects on the target cell and indirect effects on the host (immunosuppression). Recent studies have begun to uncover the molecular mechanisms involved. Here, we discuss recent findings and developments in the molecular biology of UV-carcinogenesis in the skin, by focusing on DNA damage and DNA repair, the p53 tumor suppressor gene, apoptosis, the patched gene and telomerase activity.

KW - Carcinogenesis

KW - DNA repair

KW - Ltraviolet light

KW - P53

KW - Patched gene

KW - Skin cancer

KW - Telomerase

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DO - 10.13181/mji.v9i2.664

M3 - Article

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SN - 0853-1773

VL - 9

SP - 118

EP - 132

JO - Medical Journal of Indonesia

JF - Medical Journal of Indonesia

IS - 2

ER -

Molecular pathological changes induced by ultraviolet light during the development of skin cancer

Abstract

Keywords

UN SDGs

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