@inproceedings{46d568125c304de0913993cf48eb6d2d,
title = "Molecular interaction study of commercial cyclic peptides and MERS-COV papain-like protease as novel drug candidate for MERS-COV",
abstract = "Middle-east respiratory syndrome coronavirus (MERS-CoV) has become the current outbreak, MERS-CoV infection results in illness at the respiratory system, digestive, and even lead to death with an average mortality caused by MERS-CoV infection reaches 50 %. Until now, there is not any effective vaccine or drug to ward off MERS-CoV infection. Papain-like protease (PLpro) is responsible for cleavage of a nonstructural protein that is essential for viral maturation. Inhibition of PLpro with a ligand will block the cleavage process of nonstructural protein, thus reduce the infection of MERS-CoV. Through of bioinformatics study with molecular docking and binding interaction analysis of commercial cyclic peptides, aldosterone secretion inhibiting factor (1-35) (bovine) was obtained as an inhibitor for PLpro. Thus, aldosterone secretion inhibiting factor (1-35) (bovine) has a potential as a novel candidate drug for treating MERS-CoV.",
keywords = "MERS-CoV, commercial cyclic peptide, drug scan analysis, molecular docking, papain-like protease (PL)",
author = "Nasution, {M. A.F.} and Azzuhdi, {M. G.} and Friend, {Usman Sumo}",
note = "Publisher Copyright: {\textcopyright} 2017 Author(s).; 2nd International Symposium on Current Progress in Mathematics and Sciences 2016, ISCPMS 2016 ; Conference date: 01-11-2016 Through 02-11-2016",
year = "2017",
month = jul,
day = "10",
doi = "10.1063/1.4991182",
language = "English",
series = "AIP Conference Proceedings",
publisher = "American Institute of Physics Inc.",
editor = "Sugeng, {Kiki Ariyanti} and Djoko Triyono and Terry Mart",
booktitle = "International Symposium on Current Progress in Mathematics and Sciences 2016, ISCPMS 2016",
address = "United States",
}
