Molecular genetics of craniosynostosis

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Tight regulation process and complex interplay occur along the osteogenic interfaces of the cranial sutures in normal growth and development of the skull. Cranial sutures serve as sites of bone growth while maintaining a state of patency to accommodate the developing brain. Cranial sutures are fibro-cellular structures that separate the rigid plates of the skull bones. Premature fusion of one or more cranial sutures leads to a condition known as craniosynostosis. Craniosynostosis is one of the most common craniofacial anomalies with a prevalence of 1 in 2,500 newborns. Several genes have been identified in the pathogenesis of craniosynostosis. Molecular signaling events and the intracellular signal transduction pathways implicated in the suture pathobiology will provide a useful approach for therapeutic targeting.

Original languageEnglish
Article number012037
JournalIOP Conference Series: Earth and Environmental Science
Issue number1
Publication statusPublished - 26 Mar 2018
Event3rd International Conference on Biological Sciences and Biotechnology, ICBSB 2017 - Medan, Indonesia
Duration: 23 Aug 201724 Aug 2017


  • cranial development
  • cranial sutures
  • signalling mechanism
  • sutures fusion


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