TY - JOUR
T1 - Molecular genetics and epigenetics of temporomandibular disorder
AU - Antolis, M.
AU - Langit, K. S.
AU - Gultom, F. P.
AU - Auerkari, E. I.
N1 - Funding Information:
Genetic analysis and biomarkers of temporomandibular disorder could improve sensitivity and specificity metrics when diagnosing and treating TMD patient. Therefore, further research is suggested before genetic molecular reaches their full potential in any clinical application.Acknowledgments The authors wish to gratefully acknowledge financial support from the University of Indonesia to EIA.
Publisher Copyright:
© Published under licence by IOP Publishing Ltd.
PY - 2021/7/14
Y1 - 2021/7/14
N2 - Temporomandibular joint (TMJ) has an important role in stomatognathic system. Its role during function is facilitated from rotation and translation movement. Any deviation from TMJ normal anatomy and movement could lead into either clicking, crepitus, or pain in preauricular area. These sign and symptoms, which are widely referred as TMJ Temporomandibular joint disorder (TMD), extremely common in world population. Several genes have been identified contribute in susceptibility towards TMD. Genetic polymorphism are a form of gene sequences variance that is found in more than 1% of world population. Epigenetics is an interaction between internal and external environments that leads to a change in chromatin structures that switches the gene expression on and off. There are several factors that posibly affect the genetic polymorphisms in TMD such as; serotonin, cathecolamine, estrogen, folate, human leukocyte antigen (HLA), extracellular matrix, transcription factors, transforming growth factor beta (TGFβ), epithelial growth factor, β-catenin, and discoidin. Epigenetic mechanisms such as DNA methylation, histone modification, and microRNA are found in chondrocyte of TMD patients. In a temporomandibular joint, miRNA-140 controls bone homeostasis especially on the articular remodeling. Genetic molecular and epigenetic study will benefit in diagnosis and treatment of TMD patient. The aim of this paper is author want to inform about molecular genetics and epigenetics of TMD.
AB - Temporomandibular joint (TMJ) has an important role in stomatognathic system. Its role during function is facilitated from rotation and translation movement. Any deviation from TMJ normal anatomy and movement could lead into either clicking, crepitus, or pain in preauricular area. These sign and symptoms, which are widely referred as TMJ Temporomandibular joint disorder (TMD), extremely common in world population. Several genes have been identified contribute in susceptibility towards TMD. Genetic polymorphism are a form of gene sequences variance that is found in more than 1% of world population. Epigenetics is an interaction between internal and external environments that leads to a change in chromatin structures that switches the gene expression on and off. There are several factors that posibly affect the genetic polymorphisms in TMD such as; serotonin, cathecolamine, estrogen, folate, human leukocyte antigen (HLA), extracellular matrix, transcription factors, transforming growth factor beta (TGFβ), epithelial growth factor, β-catenin, and discoidin. Epigenetic mechanisms such as DNA methylation, histone modification, and microRNA are found in chondrocyte of TMD patients. In a temporomandibular joint, miRNA-140 controls bone homeostasis especially on the articular remodeling. Genetic molecular and epigenetic study will benefit in diagnosis and treatment of TMD patient. The aim of this paper is author want to inform about molecular genetics and epigenetics of TMD.
UR - http://www.scopus.com/inward/record.url?scp=85112006291&partnerID=8YFLogxK
U2 - 10.1088/1742-6596/1943/1/012085
DO - 10.1088/1742-6596/1943/1/012085
M3 - Conference article
AN - SCOPUS:85112006291
SN - 1742-6588
VL - 1943
JO - Journal of Physics: Conference Series
JF - Journal of Physics: Conference Series
IS - 1
M1 - 012085
T2 - 10th International Seminar on New Paradigm and Innovation of Natural Sciences and itsApplication, ISNPINSA 2020
Y2 - 24 September 2020 through 25 September 2020
ER -